Ignite Creation Date:
2025-12-24 @ 2:49 PM
Ignite Modification Date:
2025-12-29 @ 12:15 AM
Study NCT ID:
NCT05429359
Status:
UNKNOWN
Last Update Posted:
2022-09-06
First Post:
2022-06-17
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
cArdiopulmonary exerCise Test Assessing Multiple biOmarkers and Hormones iN Type 1 diabetEs Under Different Circumstances
Sponsor:
University Hospital, Antwerp
Organization:
Study Overview
Official Title:
cArdiopulmonary exerCise Test Assessing Multiple biOmarkers and Hormones iN Type 1 diabetEs Under Different Circumstances (ACT-ONE)
Status:
UNKNOWN
Status Verified Date:
2022-06
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ACT-ONE
Brief Summary:
Collection of venous blood samples in 50 persons with type 1 diabetes to evaluate the behavior of different biomarkers (glucose, lactate, beta-hydroxybutyrate), and hormones (cortisol, growth hormone) during and after one morning CardioPulmonary Exercise Test and 2 aerobic (90 minutes at 40-45% of VO2 max) exercise tests under different circumstances (see Protocol).
Detailed Description:
This study is an extension of the Action-1 pilot study. This study is an extension of the Action-1 pilot study. The aim is to collect samples of multiple biomarkers (circulating glucose, ketones and lactate levels) and hormones (cortisol and growth hormone) during and following an anaerobic and two aerobic exercise in patients with T1D, under more and well-defined circumstances (bolus insulin reduction in combination with major vs. minor basal insulin reduction) to aim for safer glucose levels during and after exercise (\~90-180 mg/dL or \~5-10 mmol/L) and avoid extreme glucose excursions to hypo (\< 70 mg/dL or \<3.9 mmol/L) or hyperglycemia (\>180 mg/dL or \>10 mmol/L). Based on these data, we aim to formulate exercise guidelines to better help prevent hypoglycemia during and after exercise. Overall, our goal is to help maintain target glycemic values during and after exercise, as evidenced by \>70% time in range (70-180mg/dL) while using Continuous Glucose Monitoring (CGM).
Primary endpoint:
• CGM outcomes during and after morning exercise, determined as:
* Time in range (TIR) 70-180mg/dL
* Time below range (TBR) Level 2, \<54 mg/dL
* Time below range (TBR) Level 1 and 2, \<70 mg/dL
* Time above range (TAR) Level 1 and 2, \>180 mg/dL
* Time above range (TAR) Level 2, \>250 mg/dL
Secondary endpoints:
* Evaluate values and trends of glucose, lactate and beta-hydroxybutyrate before, during and after morning exercise in venous blood.
* Evaluate trends of cortisol and growth hormone before, during and after exercise in relationship to possible hypoglycemic (\<70mg/dL glucose) and hyperglycemic events (\>180mg/dL).
One CardioPulmonary Exercise Test (CPET, symptom limited maximal exercise test) and two Aerobic Exercise Tests at 40-45% VO2max (AEX), with venous blood samples (catheter), heart rate monitoring during the exercise and follow-up to 6h after the exercise.
(The individual VO2max, using a CardioPulmonary Exercise Test, can be determined during the first "Symptom Limited Maximal" Exercise Test. This to assess the VT1 (V-slope relation VCO2 and VO2; Eq02), VT2 (Relation VE and VCO2; EqCO2) and VO2 peak.)
Before exercise Test 1, the CPET, the study participants will receive 7 questions on the physical activity over the last 7 days (IPAQ questionnaire).
The 3 Exercise Tests will be carried out with 2-4 weeks intervals:
* The day before an exercise test and right before, no exercise (only ADL) is allowed (patients should not come to the study center by bike)
* The night before the exercise test, no hypoglycemia must occur, as defined by 15 consecutive minutes, or more, of an interstitial glucose \<70 mg/dL
* Target glucose level in the morning: 90-180 mg/dL
* The morning of the exercise test: patients will receive a standardized breakfast (slices of bread with protein spread (containing ±5-25g of protein in total) of in total 0.5g carbohydrates per kg body weight)
* Breakfast at 30 minutes before the exercise with a bolus at the start of the breakfast (100% bolus for CPET, 50% bolus for AEX)
* Pump settings: basal insulin reduction through temporary target of 150 mg/dL during AEX1 and AEX2 will be adjusted 60-120 minutes prior to the start of the exercise and will last until 60 minutes after the exercise (210-270 min in total)
* Lunch (slices of bread with protein spread (containing ±5-25g of protein in total) of in total 0.5g carbohydrates per kg body weight) will be served after 2h of follow-up with a 75% insulin bolus and a correction bolus, if necessary, of 50% of the patient's usual insulin correction dose for the level of hyperglycemia observed.
* Hyperglycemia (\>250mg/dL) before, during and after exercise will be corrected according to the patient's treatment schedule at 50% of the patient's usual correction factor.
* Glucose levels below the target glucose of 90 mg/dL during exercise will be corrected with fast-acting carbohydrates: 15g of oral glucose (sports beverage Aquarius Red Peach (7.4g CHO/100ml)), as repeated every 15 minutes, if necessary, until interstitial and/or whole blood glucose is \> 70 mg/dL.
CPET:
* Baseline
* VO2peak measurement
* Breakfast
* 100% bolus insulin
* CSII: 100% basal
* MDI: 100% basal
AEX1:
* 90min
* 40-45% VO2peak
* Breakfast
* 50% bolus insulin
* CSII: -2h target 150 mg/dL
* MDI: 50% basal
AEX2:
* 90min
* 40-45% VO2peak
* Breakfast
* 50% bolus insulin
* CSII: -1h target 150 mg/dL
* MDI: 80% basal
CPET = CardioPulmonary Exercise Test; AEX = Aerobic Exercise Test; CSII = Continuous Subcutaneous Insulin Infusion (only hybrid closed loop pumps); MDI = Multiple Daily Injections (only Tresiba and Toujeo as basal insulin)
Primary endpoint:
• CGM outcomes during and after morning exercise, determined as:
* Time in range (TIR) 70-180mg/dL
* Time below range (TBR) Level 2, \<54 mg/dL
* Time below range (TBR) Level 1 and 2, \<70 mg/dL
* Time above range (TAR) Level 1 and 2, \>180 mg/dL
* Time above range (TAR) Level 2, \>250 mg/dL
Secondary endpoints:
* Evaluate values and trends of glucose, lactate and beta-hydroxybutyrate before, during and after morning exercise in venous blood.
* Evaluate trends of cortisol and growth hormone before, during and after exercise in relationship to possible hypoglycemic (\<70mg/dL glucose) and hyperglycemic events (\>180mg/dL).
One CardioPulmonary Exercise Test (CPET, symptom limited maximal exercise test) and two Aerobic Exercise Tests at 40-45% VO2max (AEX), with venous blood samples (catheter), heart rate monitoring during the exercise and follow-up to 6h after the exercise.
(The individual VO2max, using a CardioPulmonary Exercise Test, can be determined during the first "Symptom Limited Maximal" Exercise Test. This to assess the VT1 (V-slope relation VCO2 and VO2; Eq02), VT2 (Relation VE and VCO2; EqCO2) and VO2 peak.)
Before exercise Test 1, the CPET, the study participants will receive 7 questions on the physical activity over the last 7 days (IPAQ questionnaire).
The 3 Exercise Tests will be carried out with 2-4 weeks intervals:
* The day before an exercise test and right before, no exercise (only ADL) is allowed (patients should not come to the study center by bike)
* The night before the exercise test, no hypoglycemia must occur, as defined by 15 consecutive minutes, or more, of an interstitial glucose \<70 mg/dL
* Target glucose level in the morning: 90-180 mg/dL
* The morning of the exercise test: patients will receive a standardized breakfast (slices of bread with protein spread (containing ±5-25g of protein in total) of in total 0.5g carbohydrates per kg body weight)
* Breakfast at 30 minutes before the exercise with a bolus at the start of the breakfast (100% bolus for CPET, 50% bolus for AEX)
* Pump settings: basal insulin reduction through temporary target of 150 mg/dL during AEX1 and AEX2 will be adjusted 60-120 minutes prior to the start of the exercise and will last until 60 minutes after the exercise (210-270 min in total)
* Lunch (slices of bread with protein spread (containing ±5-25g of protein in total) of in total 0.5g carbohydrates per kg body weight) will be served after 2h of follow-up with a 75% insulin bolus and a correction bolus, if necessary, of 50% of the patient's usual insulin correction dose for the level of hyperglycemia observed.
* Hyperglycemia (\>250mg/dL) before, during and after exercise will be corrected according to the patient's treatment schedule at 50% of the patient's usual correction factor.
* Glucose levels below the target glucose of 90 mg/dL during exercise will be corrected with fast-acting carbohydrates: 15g of oral glucose (sports beverage Aquarius Red Peach (7.4g CHO/100ml)), as repeated every 15 minutes, if necessary, until interstitial and/or whole blood glucose is \> 70 mg/dL.
CPET:
* Baseline
* VO2peak measurement
* Breakfast
* 100% bolus insulin
* CSII: 100% basal
* MDI: 100% basal
AEX1:
* 90min
* 40-45% VO2peak
* Breakfast
* 50% bolus insulin
* CSII: -2h target 150 mg/dL
* MDI: 50% basal
AEX2:
* 90min
* 40-45% VO2peak
* Breakfast
* 50% bolus insulin
* CSII: -1h target 150 mg/dL
* MDI: 80% basal
CPET = CardioPulmonary Exercise Test; AEX = Aerobic Exercise Test; CSII = Continuous Subcutaneous Insulin Infusion (only hybrid closed loop pumps); MDI = Multiple Daily Injections (only Tresiba and Toujeo as basal insulin)
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: