Ignite Creation Date:
2024-05-06 @ 1:18 AM
Last Modification Date:
2024-10-26 @ 11:01 AM
Study NCT ID:
NCT01771380
Status:
COMPLETED
Last Update Posted:
2015-09-22
First Post:
2013-01-10
Brief Title:
Measurement of the Free Fraction of 25-hydroxyvitamin D in Serum
Sponsor:
University of Tromso
Organization:
University of Tromso
Study Overview
Official Title:
Measurement of the Free Fraction of 25-hydroxyvitamin D in Serum
Status:
COMPLETED
Status Verified Date:
2015-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In the circulation 25-hydroxyvitaminD 25OHD is bound to the vitamin D binding protein DBP and albumin According to the free hormone hypothesis it is however the free fraction that is biologically active Polymorphisms in DBP are related to the serum level of 25OHD As these polymorphisms may also affect the binding affinities for 25OHD the total serum 25OHD may not necessary reflect the free fraction To test this hypothesis we will calculate the free fraction of 25OHD by correction for DBP and albumin content and also measure free 25OHD from equilibrium dialysis and ultra filtration Furthermore we will relate total serum 25OHD as well as the free and biologically active free- albumin-bound 25OHD to the well established vitamin D effect marker serum parathyroid hormone as well as to the RNA expression in peripheral blood to evaluate the biological importance of the free versus the total fraction of 25OHD We will invite 300 subjects from an ongoing vitamin D supplementation study to participate in the study which will be one visit only and include collection of blood samples
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None