Ignite Creation Date:
2024-05-05 @ 11:45 AM
Last Modification Date:
2024-10-26 @ 9:13 AM
Study NCT ID:
NCT00125658
Status:
COMPLETED
Last Update Posted:
2017-06-23
First Post:
2005-07-28
Brief Title:
Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis
Sponsor:
VA Office of Research and Development
Organization:
VA Office of Research and Development
Study Overview
Official Title:
Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis
Status:
COMPLETED
Status Verified Date:
2017-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The results of this study will provide sound scientific evidence of physiologic mechanisms responsible for upper-extremity weakness evidence of the processes involved in neuromuscular adaptation and will elucidate the relationship between impairment and motor disability in post-stroke hemiparesis
Detailed Description:
This proposal extends the work accomplished in our initial study project B2405R Effects of Strength Training on Upper-limb Function in Post-stroke Hemiparesis In the present study we will conduct a double-blind randomized clinical trial of staged rehabilitation for the upper-extremity involving sequential delivery of functional therapy and high intensity resistance training Therefore this proposal directly compares the effects of functional and resistance training delivered individually The researchers previous work investigated a hybrid therapy of functional and resistance training against functional training alone All subjects will participate in a 5 week run-in period of no treatment This no-treatment block will afford multiple baseline measurements and in addition will provide information regarding the rate and magnitude of any spontaneous recovery without treatment Following the second baseline measurement all subjects will be randomized to upper-extremity rehabilitation in either Order A - 10 weeks of functional task practice training FTP followed by 10 weeks of high-intensity resistance training Power or Order B - resistance training Power followed by FTP Re-evaluation will occur following each block of treatmentand retention effects will be evaluated after 6 and 12 months with no additional treatment Subjects will be evaluated with outcome measures used broadly in Clinical Neurology and Rehabilitation a battery of biomechanical performance measures including strength muscle activation reflex modulation and motor coordination and with kinematics of free reaching movements The researchers will investigate persons in the intermediate phase of recovery which they define as between 6 and 18 months post-stroke having completed all inpatient and outpatient therapies with remaining residual motor deficits
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None