Ignite Creation Date:
2024-05-06 @ 1:14 AM
Last Modification Date:
2024-10-26 @ 11:01 AM
Study NCT ID:
NCT01763541
Status:
WITHDRAWN
Last Update Posted:
2017-10-19
First Post:
2012-11-13
Brief Title:
Study of the Effect of Testosterone and Estradiol on NP Responses to Acute and Chronic Salt Loading
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
Gonadal Steroid Regulation of the Natriuretic Peptide System
Status:
WITHDRAWN
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is gender dimorphism in cardiovascular risk with men at higher risk than women However the fundamental basis for the protective effect of female sex remains unclear Recent data implicate the natriuretic peptide NP system as an important determinant of blood pressure Also NP levels are twice as high in women of reproductive age than in men and gonadal steroids are important determinants of circulating NPs These are the marked but poorly understood differences in the NP status between men and women The investigators hypothesize that gonadal steroids regulate NP release specifically that testosterone inhibits and estrogen activates the NP axis leading to differences in both resting NP levels and dynamic responses of the NP RAAS and kidneys to acute and chronic salt loading Understanding the basis for gender differences in NP function should provide important insights regarding mechanisms underlying hypertension in men versus women
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None