Ignite Creation Date:
2024-05-05 @ 11:45 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00121394
Status:
COMPLETED
Last Update Posted:
2014-07-31
First Post:
2005-07-15
Brief Title:
Chlorhexidine Vaginal and Infant Wash in Pakistan
Sponsor:
NICHD Global Network for Womens and Childrens Health
Organization:
NICHD Global Network for Womens and Childrens Health
Study Overview
Official Title:
Randomized Trial of Chlorhexidine Vaginal and Infant Wash to Reduce Neonatal Mortality
Status:
COMPLETED
Status Verified Date:
2014-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Infection is a major health problem during birth in Pakistan This study will look at the possibility of using a septic wash to help improve health during birth in Karachi Pakistan
Detailed Description:
Sepsis in mother and infant is a major cause of perinatal morbidity and mortality in low-resource settings Several studies have investigated the likelihood that an anti-bacterial agent chlorhexidine administered during labor and delivery to mother and infant could reduce the risk of infection and of subsequent maternal and infant morbidity and mortality In this trial chlorhexidine wash and placebo will be randomly administered to women in labor and newborn infants in a public hospital in Karachi Pakistan
Delivery attendants will administer 06 chlorhexidine solution every four hours until delivery 4 washes maximum and one neonatal wash with the same solution The control group will receive 200 ml of sterile physiologic saline solution A total of 5000 women will be randomized in the hospital study 2500 control and 2500 intervention All women and infants will be evaluated 24 hours post delivery and at a 7-day follow-up Women who delivered at home will also receive a 28 days post-partum assessment Women will be carefully monitored for side effects to the dosage In addition a community-based feasibility trial of 200 patients 100 CHX 100 control will be completed
Delivery attendants will administer 06 chlorhexidine solution every four hours until delivery 4 washes maximum and one neonatal wash with the same solution The control group will receive 200 ml of sterile physiologic saline solution A total of 5000 women will be randomized in the hospital study 2500 control and 2500 intervention All women and infants will be evaluated 24 hours post delivery and at a 7-day follow-up Women who delivered at home will also receive a 28 days post-partum assessment Women will be carefully monitored for side effects to the dosage In addition a community-based feasibility trial of 200 patients 100 CHX 100 control will be completed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U01HD040607 | NIH | None | httpsreporternihgovquickSearchU01HD040607 |