Ignite Creation Date:
2024-05-06 @ 1:11 AM
Last Modification Date:
2024-10-26 @ 11:01 AM
Study NCT ID:
NCT01758016
Status:
UNKNOWN
Last Update Posted:
2015-10-07
First Post:
2012-12-23
Brief Title:
Haptoglobin and Diabetes Complications in Pregnancy
Sponsor:
Rambam Health Care Campus
Organization:
Rambam Health Care Campus
Study Overview
Official Title:
Haptoglobin and Diabetes Complications in Pregnancy
Status:
UNKNOWN
Status Verified Date:
2015-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pregnancies of patients with Diabetes are associated with increase adverse pregnancy outcome The risk for vascular complications including Intra uterine growth restriction 20 hypertension 31 preeclampsia 15 eclampsia and placental abruption are significantly greater than those in background populations The risk of developing vascular complications in diabetes pregnancies although is correlated with the severity and length of the disease is not fully understood Enhanced oxidation has been suggested to be the underlying abnormality responsible for some of the complications of diabetes
Haptoglobin Hp is an abundant plasma glycoprotein produced in the liver The best understood function of Hp is to bind free hemoglobin Hb released from red blood cells Extracorpuscular Hb is a potent Fenton reagentcapable of of inflicting oxidative tissue damage Hp binds to Hb and serves to inhibit the oxidative potential of Hb by preventing the release of heme iron
The haptoglobin Hp gene at chromosomal locus 16q22 is polymorphic with two common alleles denoted 1 and 2 the prevalence of Hp 1-1 Hp 1-2 and Hp 2-2 genotypes is approximately 16 48 and 36 respectively In the western world A total of five independent longitudinal studies have demonstrated that DM individuals with Hp 2-2 genotype have a two to five-fold increased risk of CVD as compared to DM individuals without the Hp 2-2 genotype We sought to determine whether HP genotype plays important role in development of vascular complications in pregastational pregnancies and whether Hp genotype 2-2 is a risk factor for developing gestational diabetes GDM
Haptoglobin Hp is an abundant plasma glycoprotein produced in the liver The best understood function of Hp is to bind free hemoglobin Hb released from red blood cells Extracorpuscular Hb is a potent Fenton reagentcapable of of inflicting oxidative tissue damage Hp binds to Hb and serves to inhibit the oxidative potential of Hb by preventing the release of heme iron
The haptoglobin Hp gene at chromosomal locus 16q22 is polymorphic with two common alleles denoted 1 and 2 the prevalence of Hp 1-1 Hp 1-2 and Hp 2-2 genotypes is approximately 16 48 and 36 respectively In the western world A total of five independent longitudinal studies have demonstrated that DM individuals with Hp 2-2 genotype have a two to five-fold increased risk of CVD as compared to DM individuals without the Hp 2-2 genotype We sought to determine whether HP genotype plays important role in development of vascular complications in pregastational pregnancies and whether Hp genotype 2-2 is a risk factor for developing gestational diabetes GDM
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None