Ignite Creation Date:
2024-05-05 @ 11:45 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00124163
Status:
UNKNOWN
Last Update Posted:
2006-02-02
First Post:
2005-07-25
Brief Title:
Evaluation of Stool Tagging for Improved Patient Compliance
Sponsor:
Center for Diagnostic Imaging
Organization:
Center for Diagnostic Imaging
Study Overview
Official Title:
CT Colonography Ph I CDI Trial Evaluation of Stool Tagging for Improved Patient Compliance
Status:
UNKNOWN
Status Verified Date:
2006-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Computed tomography CT colonography has gained widespread multi-disciplinary interest as an evolving noninvasive colorectal screening examination with the potential of improved patient compliance The investigators prior work demonstrated that the bowel preparation was the least tolerable aspect of colorectal evaluation when compared to the CT colonography and optical colonoscopy procedures Stool tagging could provide a more gentle and efficient bowel preparation with fewer false positives due to retained stool-mimicking polyps
The researchers hypothesize that image quality and patient preference will vary with stool tagging concentration and dosing schedule The researchers propose to evaluate specific stool tagging protocols with the following aims
AIM 1 Perform a randomized trial of three specific stool tagging protocols using barium and iodine at CT colonography in a well-characterized cohort of patients undergoing colorectal evaluation
AIM 2 Analyze the CT colonography and optical colonoscopy data to assess differences across stool tagging protocols for the outcome measures of patient preference image quality in the presence of tagging and diagnostic reader performance
The researchers will use specific variations in stool tagging techniques to determine the best image quality of CT data eg homogenous tagging of fluid and stool and highest patient acceptability as well as evaluate the adequacy of preparation for same-day colonoscopy Diagnostic reader performance will focus on the accuracy for detecting all neoplastic lesions including colon cancers adenomatous polyps sessile adenomas and flat adenomas Most importantly these results will help inform the design of a larger trial of an optimized CT colonography technique in a community setting
The researchers hypothesize that image quality and patient preference will vary with stool tagging concentration and dosing schedule The researchers propose to evaluate specific stool tagging protocols with the following aims
AIM 1 Perform a randomized trial of three specific stool tagging protocols using barium and iodine at CT colonography in a well-characterized cohort of patients undergoing colorectal evaluation
AIM 2 Analyze the CT colonography and optical colonoscopy data to assess differences across stool tagging protocols for the outcome measures of patient preference image quality in the presence of tagging and diagnostic reader performance
The researchers will use specific variations in stool tagging techniques to determine the best image quality of CT data eg homogenous tagging of fluid and stool and highest patient acceptability as well as evaluate the adequacy of preparation for same-day colonoscopy Diagnostic reader performance will focus on the accuracy for detecting all neoplastic lesions including colon cancers adenomatous polyps sessile adenomas and flat adenomas Most importantly these results will help inform the design of a larger trial of an optimized CT colonography technique in a community setting
Detailed Description:
CT Colonography a rapidly evolving technique offers a noninvasive and efficient colorectal screening examination with the potential to improve patient compliance However currently it requires the bowel preparation one of the largest barriers to colonoscopy screening A promising new tool in CT Colonography is stool tagging which has the potential to decrease the amount of catharsis required by patients during the bowel preparation while decreasing the number of false positives due to the reader mistaking residual stool for polyps
Our primary hypothesis is that image quality and patient compliance differ depending upon the tagging agent and dosing schedule Our strategy is to vary key components of recently reported barium and iodine protocols to further optimize them and to compare our results with existing and currently aggregating data in collaboration with other investigators
The following aims will implement this strategy
AIM 1 Perform a randomized control trial of specific stool tagging protocols at CT Colonography in a well characterized cohort of patients undergoing colorectal evaluation
Task 1A - Recruit a prospective cohort of 60 subjects randomize them equally to three different stool tagging protocols and sequentially perform CT Colonography and optical colonoscopy on them
Task 1B - Assess image quality of CT Colonography and optical colonoscopy data by the method of bowel preparation in the first five subjects of each arm and implement specific changes if necessary
AIM 2 Analyze the CT Colonography and optical colonoscopy data to assess differences across study arms for the outcome measures of patient preference image quality of tagged stool and diagnostic reader performance
Task 2A Assess patient expectations regarding the bowel preparations CT Colonography and colonoscopy before the procedures and their preferences after the procedures
Task 2B Evaluate image quality in the presence of tagged stool and fluid of both the CT data and the colonoscopy data
Task 2C Perform a multi-observer reader evaluation of diagnostic performance of CT Colonography and colonoscopy compared to the enhanced reference standard of colonoscopy aided by segmental unblinding of CT results to assess sensitivity and specificity of colorectal polyp detection
Upon completion the three specific variations in stool tagging techniques will be compared on homogenous density of tagging and patient acceptability to determine which protocol optimizes the trade-off Diagnostic performance of CT and colonoscopy will be compared to the enhanced reference standard of colonoscopy aided by the segmental unblinding of CT results Most significantly these results may help determine an optimal tagging protocol to use for larger trials of CT Colonography implementation in community settings
Our primary hypothesis is that image quality and patient compliance differ depending upon the tagging agent and dosing schedule Our strategy is to vary key components of recently reported barium and iodine protocols to further optimize them and to compare our results with existing and currently aggregating data in collaboration with other investigators
The following aims will implement this strategy
AIM 1 Perform a randomized control trial of specific stool tagging protocols at CT Colonography in a well characterized cohort of patients undergoing colorectal evaluation
Task 1A - Recruit a prospective cohort of 60 subjects randomize them equally to three different stool tagging protocols and sequentially perform CT Colonography and optical colonoscopy on them
Task 1B - Assess image quality of CT Colonography and optical colonoscopy data by the method of bowel preparation in the first five subjects of each arm and implement specific changes if necessary
AIM 2 Analyze the CT Colonography and optical colonoscopy data to assess differences across study arms for the outcome measures of patient preference image quality of tagged stool and diagnostic reader performance
Task 2A Assess patient expectations regarding the bowel preparations CT Colonography and colonoscopy before the procedures and their preferences after the procedures
Task 2B Evaluate image quality in the presence of tagged stool and fluid of both the CT data and the colonoscopy data
Task 2C Perform a multi-observer reader evaluation of diagnostic performance of CT Colonography and colonoscopy compared to the enhanced reference standard of colonoscopy aided by segmental unblinding of CT results to assess sensitivity and specificity of colorectal polyp detection
Upon completion the three specific variations in stool tagging techniques will be compared on homogenous density of tagging and patient acceptability to determine which protocol optimizes the trade-off Diagnostic performance of CT and colonoscopy will be compared to the enhanced reference standard of colonoscopy aided by the segmental unblinding of CT results Most significantly these results may help determine an optimal tagging protocol to use for larger trials of CT Colonography implementation in community settings
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None