Ignite Creation Date:
2024-05-05 @ 11:45 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00122473
Status:
COMPLETED
Last Update Posted:
2011-07-29
First Post:
2005-07-20
Brief Title:
Imatinib in Dermatofibrosarcoma Protuberans DFSP
Sponsor:
Dermatologic Cooperative Oncology Group
Organization:
Dermatologic Cooperative Oncology Group
Study Overview
Official Title:
Open-label Trial of Glivec Imatinib Mesylate in Patients With Primary or Recurrent Dermatofibrosarcoma Protuberans
Status:
COMPLETED
Status Verified Date:
2011-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether imatinib is effective in the treatment of primary and recurrent dermatofibrosarcoma protuberans DFSP
Detailed Description:
This study is aimed to investigate the efficacy of imatinib Glivec in the treatment of primary and locally relapsed dermatofibrosarcoma protuberans DFSP DFSP is a cutaneous neoplasm well known for its overexpression of the platelet-derived growth factor PDGF Herein imatinib provides a systemic treatment option that offers the possibility of a reduction of the wide surgical margins used today in surgery of primary DFSP or even of a complete avoidance of surgical treatment in this disease Since imatinib exerts its function via interference with protein tyrosine kinase activities it inhibits the platelet-derived growth factor receptor PDGF-R signaling cascade that plays a crucial role in the pathogenesis and tumor growth of DFSP Since imatinib has been shown to shrink metastatic lesions of DFSP there is a strong rationale to expect that it also decreases cell proliferation and tumor growth in primary DFSP
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| CSTI571BDE25 | None | None | None |