Ignite Creation Date:
2024-05-05 @ 10:01 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005428
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Familial Aggregation of Stress Response
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To perform data analyses on the familial aggregation of the stress response as it relates to hypertension
Detailed Description:
BACKGROUND
Given recent advances in the analyses of genetic epidemiologic data the database presented a unique opportunity to address timely issues pertinent to the contribution of genetic and environmental factors to individual differences in cardiovascular reactivity
DESIGN NARRATIVE
Secondary data analyses were performed on family data obtained in an ongoing hypertension genetic study conducted at the University of Utah with Roger R Williams as principal investigator The available data represented one of the largest studies of cardiovascular reactivity among genetically related individuals During 1981-83 a total of 2548 subjects members of 98 extended families multiple generations and multiple nuclear families participated in an extensive cardiovascular examination and were assessed on a comprehensive battery of cardiovascular tests Annual follow-up questionnaires obtained information about the onset of hypertension and new medication prescribed In 1991-92 a follow-up exam was conducted on 1500 subjects
The data analysis attempted to confirm or refute hypotheses postulating a reactivity-hypertension association investigated whether there was a sex limitation in the genetic and environmental determinants of reactivity explored genotype-by-age interactions in the control of reactivityand determined whether there was shared genetic andor environmental variance between reactivity and other recognized cardiovascular risk factors such as obesity or lipids
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Given recent advances in the analyses of genetic epidemiologic data the database presented a unique opportunity to address timely issues pertinent to the contribution of genetic and environmental factors to individual differences in cardiovascular reactivity
DESIGN NARRATIVE
Secondary data analyses were performed on family data obtained in an ongoing hypertension genetic study conducted at the University of Utah with Roger R Williams as principal investigator The available data represented one of the largest studies of cardiovascular reactivity among genetically related individuals During 1981-83 a total of 2548 subjects members of 98 extended families multiple generations and multiple nuclear families participated in an extensive cardiovascular examination and were assessed on a comprehensive battery of cardiovascular tests Annual follow-up questionnaires obtained information about the onset of hypertension and new medication prescribed In 1991-92 a follow-up exam was conducted on 1500 subjects
The data analysis attempted to confirm or refute hypotheses postulating a reactivity-hypertension association investigated whether there was a sex limitation in the genetic and environmental determinants of reactivity explored genotype-by-age interactions in the control of reactivityand determined whether there was shared genetic andor environmental variance between reactivity and other recognized cardiovascular risk factors such as obesity or lipids
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL050679 | NIH | None | httpsreporternihgovquickSearchR03HL050679 |