Ignite Creation Date:
2024-05-06 @ 1:07 AM
Last Modification Date:
2024-10-26 @ 10:59 AM
Study NCT ID:
NCT01734629
Status:
COMPLETED
Last Update Posted:
2014-12-03
First Post:
2012-11-21
Brief Title:
Pulmonary Disease in Patients Referred for Coronary CT
Sponsor:
University of Sao Paulo General Hospital
Organization:
University of Sao Paulo General Hospital
Study Overview
Official Title:
Pulmonary Disease in Patients Referred for Coronary CT and Association Between Spirometric Abnormalities and Coronary Calcium Score
Status:
COMPLETED
Status Verified Date:
2013-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Several studies show an association between chronic obstructive pulmonary disease COPD and coronary artery disease CAD Besides risk factors such as smoking both are associated with physical inactivity advanced age and systemic inflammation The use of coronary computed tomography CCT with multiple detectors is a diagnostic method for coronary disease describing the anatomy and severity of arterial obstruction One way of estimating the cardiovascular risk is coronary calcium score CCS Due to the association between COPD and CAD it is likely that many patients with IHD diagnosed by CT have reduced lung function
The aim of this observational study is to establish the correlation between the CCS and lung function It will also correlate the presence of irreversible airway obstruction with significant coronary lesions
Patients over 40 years referred to CCT who agree to participate in the study will perform a spirometry with bronchodilator and collect a blood sample to measure serum markers of inflammation and cardiovascular risk glycemia lipid profile C reactive protein CRP tumor necrosis factor-alpha TNF-Alpha and fibrinogen The data will be compared in the general population and in subgroups smokers former smokers and nonsmokers
One year after the CCT patients will be contacted by the investigators and accessed for emergency room visits hospital admissions and fatal or nonfatal coronary or respiratory events
The investigators hypothesis is that reduced lung function is independently associated with elevated CCS and is also a risk factor for increased hospital admission and coronary events
The concomitant assessment of lung function and CCS can contribute knowledge about the epidemiological association between pulmonary disease and CAD This can also add to evidence for the use of spirometry as a marker of cardiovascular risk
The aim of this observational study is to establish the correlation between the CCS and lung function It will also correlate the presence of irreversible airway obstruction with significant coronary lesions
Patients over 40 years referred to CCT who agree to participate in the study will perform a spirometry with bronchodilator and collect a blood sample to measure serum markers of inflammation and cardiovascular risk glycemia lipid profile C reactive protein CRP tumor necrosis factor-alpha TNF-Alpha and fibrinogen The data will be compared in the general population and in subgroups smokers former smokers and nonsmokers
One year after the CCT patients will be contacted by the investigators and accessed for emergency room visits hospital admissions and fatal or nonfatal coronary or respiratory events
The investigators hypothesis is that reduced lung function is independently associated with elevated CCS and is also a risk factor for increased hospital admission and coronary events
The concomitant assessment of lung function and CCS can contribute knowledge about the epidemiological association between pulmonary disease and CAD This can also add to evidence for the use of spirometry as a marker of cardiovascular risk
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 050311 | OTHER | CAPPesq HCFMUSP | None |