Ignite Creation Date:
2024-05-06 @ 1:03 AM
Last Modification Date:
2024-10-26 @ 10:58 AM
Study NCT ID:
NCT01716858
Status:
COMPLETED
Last Update Posted:
2015-07-30
First Post:
2012-10-22
Brief Title:
An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients With Schizophrenia
Sponsor:
Chiba University
Organization:
Chiba University
Study Overview
Official Title:
Sulforaphane-rich Broccoli Sprout Extract for Schizophrenia
Status:
COMPLETED
Status Verified Date:
2012-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Accumulating evidence suggests a role of oxidative stress in the pathophysiology of schizophrenia The potent antioxidant sulforaphane SFN is an organosulfur compound derived from a glucosinolate precursor found in cruciferous vegetables such as broccoli Brussels sprouts and cabbage The protection afforded by SFN is thought to be mediated via activation of the NF-E2-related factor-2 Nrf2 pathway and subsequent up-regulation of phase II detoxification enzymes and antioxidant proteins through an enhancer sequence referred to as the electrophilic responsive element or antioxidant responsive element Recently we reported that SFN could attenuate behavioral abnormalities in mice after the NMDA receptor antagonist phencyclidine Considering the potent antioxidant effects of SFN we have a hypothesis that SFN would be a potential therapeutic drug for schizophrenia The purpose of this study is to determine whether SFN-rich broccoli sprout extract have beneficial effects in patients with schizophrenia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None