Ignite Creation Date:
2024-05-06 @ 1:00 AM
Last Modification Date:
2024-10-26 @ 10:57 AM
Study NCT ID:
NCT01701154
Status:
COMPLETED
Last Update Posted:
2023-05-30
First Post:
2012-10-03
Brief Title:
The Effects of Respiratory Muscle Strength Training RMST on Inspiratory and Expiratory Muscle Strength in Adults and Children With Pompe Disease
Sponsor:
Duke University
Organization:
Duke University
Study Overview
Official Title:
The Effects of Respiratory Muscle Strength Training RMST on Inspiratory and Expiratory Muscle Strength in Adults and Children With Pompe Disease
Status:
COMPLETED
Status Verified Date:
2023-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to determine if respiratory muscle strength training will be beneficial for inspiratory and expiratory muscle strength in adults and children with Pompe disease
Detailed Description:
Respiratory muscle weakness results in substantial morbidity and mortality in individuals with almost all forms of neuromuscular disease NMD including both the infantile and adult phenotypes of Pompe disease Although individual patterns of involvement vary respiratory weakness in Pompe disease typically affects both the inspiratory and expiratory muscle systems Our pilot data in two individuals with late-onset Pompe disease suggest that RMST may be a treatment for the progressive respiratory weakness encountered in this condition
Purpose of the Study
Determine the effect of respiratory muscle strength training on maximum inspiratory pressure maximum expiratory pressure upright predicted forced vital capacity and aspects of cough function
Determine the effect of RMST on functional outcome measures of gross motor function appropriate for individual participants in terms of age and motor skills
Purpose of the Study
Determine the effect of respiratory muscle strength training on maximum inspiratory pressure maximum expiratory pressure upright predicted forced vital capacity and aspects of cough function
Determine the effect of RMST on functional outcome measures of gross motor function appropriate for individual participants in terms of age and motor skills
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None