Ignite Creation Date:
2024-05-05 @ 10:01 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001168
Status:
COMPLETED
Last Update Posted:
2024-06-28
First Post:
1999-11-03
Brief Title:
Evaluation of Lipoproteins
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Teaching Protocol for the Evaluation of Plasma Lipoproteins
Status:
COMPLETED
Status Verified Date:
2024-09-25
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Lipoproteins are particles that carry fats such as cholesterol and triglycerides through the blood stream These particles are involved in causing blood vessel disease that can lead to conditions like hardening of the arteries atherosclerosis or heart attacks myocardial infarctions
This study is designed to look closely at the factors affecting lipoproteins Researchers plan to study patients and normal volunteers by measuring lipoprotein levels in the blood Patients and volunteers will be placed on a balanced diet during the study In addition researchers plan to measure levels of various hormone and enzymes in the blood Patients and volunteers participating in the study may be asked to undergo more specific tests in order to collect more information about lipoprotein metabolism
This study may not provide direct benefits to patients and volunteers participating in it However information gathered from this study may help researchers develop better skills and techniques to diagnose and treat patients with diseases of lipoprotein metabolism
This study is designed to look closely at the factors affecting lipoproteins Researchers plan to study patients and normal volunteers by measuring lipoprotein levels in the blood Patients and volunteers will be placed on a balanced diet during the study In addition researchers plan to measure levels of various hormone and enzymes in the blood Patients and volunteers participating in the study may be asked to undergo more specific tests in order to collect more information about lipoprotein metabolism
This study may not provide direct benefits to patients and volunteers participating in it However information gathered from this study may help researchers develop better skills and techniques to diagnose and treat patients with diseases of lipoprotein metabolism
Detailed Description:
The lipoprotein transport system is vital to the delivery of the hydrophobic fats that are carried in the aqueous environment of the blood The lipoprotein particles that comprise this system are polydisperse and contain triglycerides free and esterified cholesterol phospholipids and proteins Inborn errors in the lipoprotein transport system lead to alterations in both the steady state concentrations of the various lipoproteins and in the metabolism of these particles These inborn errors lead to both hyperlipoproteinemia and hypolipoproteinemia Profound changes in the ambient lipoprotein concentrations have a variety of clinical manifestations The present study protocol is designed to permit a full evaluation of the lipids lipoproteins and apolipoproteins in patients with potential genetic defects in these processes The protocol will also permit training of students staff clinicians physician assistants nurse practitioners dieticians and post-doctoral fellows in the evaluation and treatment of patients with dyslipidemias The study population will include patients which are referred to the Lipid Service from private care providers academic institutions or the NHLBI Lipid website with any of the following potential lipid abnormalities or clinical stigmata associated with dyslipoproteinemias a increased plasma levels of cholesterol triglycerides HDL-cholesterol or LDL-cholesterol b decreased plasma concentrations of cholesterol and HDL-cholesterol c postprandial hyperlipidemia or d eruptive xanthomas xanthelasma tuberous or tendinous xanthomas or corneal opacities
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 79-H-0100 | None | None | None |