Ignite Creation Date:
2024-05-06 @ 12:58 AM
Last Modification Date:
2024-10-26 @ 10:57 AM
Study NCT ID:
NCT01703013
Status:
UNKNOWN
Last Update Posted:
2012-10-10
First Post:
2012-10-05
Brief Title:
The Significance of Defensin Alpha 4 in the Pathophysiology of the Adrenal Insufficiency in Inflammatory Lung Diseases
Sponsor:
Cantonal Hospital of St Gallen
Organization:
Cantonal Hospital of St Gallen
Study Overview
Official Title:
The Significance of Defensin Alpha 4 in the Pathophysiology of the Adrenal Insufficiency in Inflammatory Lung Diseases
Status:
UNKNOWN
Status Verified Date:
2012-10
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The pathophysiology of the adrenal insufficiency of patients with critical diseases remains unclear In a prior exploratory study investigating patients with exacerbation of chronic obstructive pulmonary disease COPD the investigators demonstrated a highly significant correlation between the expression level of Defensin-alpha 4 DEFA4 mRNA in blood and the adrenal function assessed via low-dose ACTH tests The aim of this prospective study is to demonstrate that DEFA4 measured both at the mRNA level RT-PCR and at the protein level Western blotElisa is a reliable biomarker for the prediction of adrenal insufficiency in inflammatory lung diseases patients with COPD and pneumonia
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None