Ignite Creation Date:
2024-05-06 @ 12:57 AM
Last Modification Date:
2024-10-26 @ 10:56 AM
Study NCT ID:
NCT01691612
Status:
COMPLETED
Last Update Posted:
2017-07-03
First Post:
2012-09-07
Brief Title:
Role of the Isomerase Pin-1 in the Development and Treatment of Asthma
Sponsor:
Brigham and Womens Hospital
Organization:
Brigham and Womens Hospital
Study Overview
Official Title:
Role of the Isomerase Pin-1 in the Development and Treatment of Asthma
Status:
COMPLETED
Status Verified Date:
2017-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Pin1
Brief Summary:
Pin1 is activated in asthmatic airways increasing cytokine mRNA stability and eosinophil survival This study is designed to test whether the Pin1 enzyme regulates TLRIL-1R signal pathways in multiple cells in asthma
Detailed Description:
The investigators will test their hypothesis that Pin1 regulates TLRIL-1R signaling pathways in asthma by examining Pin1 and related pathway activation in BAL-derived eosinophils after house dust mite allergen challenge The investigators will perform segmental allergen challenge BAL and lung biopsy of the allergen-challenged segments will be performed 48 hr later and activation of Pin1 and related pathways will be examined
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None