Ignite Creation Date:
2024-05-06 @ 12:57 AM
Last Modification Date:
2024-10-26 @ 10:57 AM
Study NCT ID:
NCT01698593
Status:
COMPLETED
Last Update Posted:
2012-10-03
First Post:
2012-10-01
Brief Title:
Bupivacaine Digital Blocks How Long is the Pain Relief and Temperature Elevation
Sponsor:
Lalonde Donald H MD
Organization:
Lalonde Donald H MD
Study Overview
Official Title:
Bupivacaine Digital Blocks How Long is the Pain Relief and Temperature Elevation
Status:
COMPLETED
Status Verified Date:
2012-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
No one knows how long bupivacaine finger blocks last Many use bupivacaine with and without epinephrine but no one knows how the epinephrine affects the duration of the block We also dont know how long the pain part of the block lasts which is what counts
The goal of the study is to determine the duration of action of bupivacaine digital nerve blocks with and without epinephrine on finger temperature and the sensory modalities of pain touch and pressure 2 ml of bupivacaine 05 with and without epinephrine will be injected at the base of each ring finger on the palm surface At the end of 1 hr 6 hrs 12 hrs 14 hrs and each additional hour patients will use an insulin lancet to measure pain the Semmes Weinstein monofilament test to measure light touch and pressure and a body surface thermometer to measure finger temperature The time for the finger to return to normal sensation and temperature will be measured
The goal of the study is to determine the duration of action of bupivacaine digital nerve blocks with and without epinephrine on finger temperature and the sensory modalities of pain touch and pressure 2 ml of bupivacaine 05 with and without epinephrine will be injected at the base of each ring finger on the palm surface At the end of 1 hr 6 hrs 12 hrs 14 hrs and each additional hour patients will use an insulin lancet to measure pain the Semmes Weinstein monofilament test to measure light touch and pressure and a body surface thermometer to measure finger temperature The time for the finger to return to normal sensation and temperature will be measured
Detailed Description:
Lidocaine finger blocks have been shown to provide analgesia for nearly 5 hours without epinephrine and approximately 10 hours with epinephrine - essentially doubling its duration12 The analgesic effect of epinephrine on the duration of bupivacaine finger blocks remains unknown
Bupivacaine finger injection provides a much longer duration of action than lidocaine Previous studies have shown the duration of action to be as long as 249 hours1 In the senior authors experience however patients who get bupivacaine blocks start asking for pain medication as early as 7 hours after the block Is it possible that the pain blocking effect of bupivacaine has a different duration than the touch and pressure effects The answer to this question also remains unknown
The third unknown question about bupivacaine digital blocks is their effect on fingertip temperature It has been shown that lidocaine wrist blocks increase temperature in finger tips and this has been postulated to be potentially helpful in frostbite to provide pain relief and hyperemia3 Previous studies have shown bupivacaine to exhibit vasodilatory properties at clinical concentrations of injection4-7 Does bupivacaine provide increased warmth to the finger tip How long does it last
The goals of this study are three fold 1 To determine what effect epinephrine has on the duration of bupivacaine finger block anesthesia 2 To assess the duration of action of bupivacaine with and without epinephrine on the digital sensory modalities of pain touch and pressure and 3 To assess the finger tip temperature changes that result from bupivacaine digital blocks with and without epinephrine
Bupivacaine finger injection provides a much longer duration of action than lidocaine Previous studies have shown the duration of action to be as long as 249 hours1 In the senior authors experience however patients who get bupivacaine blocks start asking for pain medication as early as 7 hours after the block Is it possible that the pain blocking effect of bupivacaine has a different duration than the touch and pressure effects The answer to this question also remains unknown
The third unknown question about bupivacaine digital blocks is their effect on fingertip temperature It has been shown that lidocaine wrist blocks increase temperature in finger tips and this has been postulated to be potentially helpful in frostbite to provide pain relief and hyperemia3 Previous studies have shown bupivacaine to exhibit vasodilatory properties at clinical concentrations of injection4-7 Does bupivacaine provide increased warmth to the finger tip How long does it last
The goals of this study are three fold 1 To determine what effect epinephrine has on the duration of bupivacaine finger block anesthesia 2 To assess the duration of action of bupivacaine with and without epinephrine on the digital sensory modalities of pain touch and pressure and 3 To assess the finger tip temperature changes that result from bupivacaine digital blocks with and without epinephrine
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None