Ignite Creation Date:
2024-05-05 @ 11:44 AM
Last Modification Date:
2024-10-26 @ 9:12 AM
Study NCT ID:
NCT00117026
Status:
COMPLETED
Last Update Posted:
2013-05-10
First Post:
2005-06-30
Brief Title:
Effects of Vitamin B1 in Type 1 Diabetic Patients
Sponsor:
University Hospital Aker
Organization:
Oslo University Hospital
Study Overview
Official Title:
Can Oral Benfotiamine Supplementation Influence Progression of Microvascular Complications in Patients With Type 1 Diabetes
Status:
COMPLETED
Status Verified Date:
2013-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine whether benfotiamine supplementation can reduce markers of microvascular complications in type 1 diabetic patients
Detailed Description:
Despite intensive strategies designed to achieve good metabolic control diabetic patients are still at a markedly increased risk of eye and kidney disease nerve damage limb amputation stroke and myocardial infarction as a result of long-term hyperglycemia It has recently been shown that supplementation with lipid soluble vitamin B1 benfotiamine in diabetic rats could effectively block three major biochemical pathways of hyperglycemic damage It has also been shown that supplementation prevented the development of experimental diabetic retinopathy and nephropathy without changes in glycemic control However the applicability of the above findings to humans is unknown and the diabetic late complications in experimental animals do not in every aspect mirror the human diabetic complications
This project will allow us to evaluate the potential of benfotiamine to reduce or prevent the further development of microvascular disease in type 1 diabetics
This project will allow us to evaluate the potential of benfotiamine to reduce or prevent the further development of microvascular disease in type 1 diabetics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None