Ignite Creation Date:
2025-12-25 @ 3:54 AM
Ignite Modification Date:
2025-12-26 @ 2:43 AM
Study NCT ID:
NCT06375902
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2025-01-24
First Post:
2024-03-15
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them
Sponsor:
IRCCS San Raffaele
Organization:
Study Overview
Official Title:
The Fragility of Metaphors (FraMe): Learning, Loosing, and How to Train Them
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FRAME
Brief Summary:
Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique
Detailed Description:
The investigators will address the following objectives:
* Primary Objective: Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique
* Secondary Objectives: 1) Evaluate the interactions between performances in metaphor comprehension and individual differences in psychopathology, cognition, ToM and functioning; 2) Test if the altered neurophysiological patterns associated to the fragility of metaphor comprehension in schizophrenia can be restored through a rehabilitative training
The investigators will enroll 32 schizophrenic patients and 32 healthy subjects as control sample.
Participants will undergo an initial visit with a specialist psychiatrist who will verify that their conditions meet the criteria required by the study. Then, subjects will be tested for metaphor comprehension, as well as for the other variables included in the study, and the electrical brain activity will be registered through a 128 channel EEG.
In the check-up visits (i.e., after the training) the following data will be collected:
* Scores relating to cognitive, pragmatic (understanding of metaphors), theory of mind and global functioning performance scores
* EEG recordings related to the process of understanding metaphors
* Scores on scales that evaluate psychopathological severity
* Primary Objective: Tracking down the difficulties in metaphor comprehension experienced by individuals with schizophrenia across different metaphor types and exploring the neurological correlates via EEG recording technique
* Secondary Objectives: 1) Evaluate the interactions between performances in metaphor comprehension and individual differences in psychopathology, cognition, ToM and functioning; 2) Test if the altered neurophysiological patterns associated to the fragility of metaphor comprehension in schizophrenia can be restored through a rehabilitative training
The investigators will enroll 32 schizophrenic patients and 32 healthy subjects as control sample.
Participants will undergo an initial visit with a specialist psychiatrist who will verify that their conditions meet the criteria required by the study. Then, subjects will be tested for metaphor comprehension, as well as for the other variables included in the study, and the electrical brain activity will be registered through a 128 channel EEG.
In the check-up visits (i.e., after the training) the following data will be collected:
* Scores relating to cognitive, pragmatic (understanding of metaphors), theory of mind and global functioning performance scores
* EEG recordings related to the process of understanding metaphors
* Scores on scales that evaluate psychopathological severity
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: