Ignite Creation Date:
2024-05-06 @ 12:54 AM
Last Modification Date:
2024-10-26 @ 10:56 AM
Study NCT ID:
NCT01683487
Status:
COMPLETED
Last Update Posted:
2014-05-28
First Post:
2012-09-07
Brief Title:
Delayed Antibiotic Treatment in Community-acquired Pneumococcal Pneumonia
Sponsor:
University of Zurich
Organization:
University of Zurich
Study Overview
Official Title:
Delayed Antibiotic Treatment in Community-acquired Pneumococcal Pneumonia Analysis of Risk Factors and Impact on the Outcome
Status:
COMPLETED
Status Verified Date:
2014-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
I To investigate time measurement from emergency room admission to first antibiotic administration
II To evaluate risk factors for prolonged time to first antibiotic administration
III To correlate time measurement with Charlson comorbidity index and multimorbidity patterns
IV To investigate the impact of a delayed time to first antibiotic administration on the outcome
II To evaluate risk factors for prolonged time to first antibiotic administration
III To correlate time measurement with Charlson comorbidity index and multimorbidity patterns
IV To investigate the impact of a delayed time to first antibiotic administration on the outcome
Detailed Description:
In this retrospective cohort study we plan to include all patients presenting with a community-acquired pneumococcal pneumonia at the University Hospital of Zurich between January 1 2006 and June 30 2012 6½ years The patients will be identified either with one or more blood culture pairs positive for S pneumoniae or with a positive pneumococcal urine antigen assay in combination with the clinical diagnosis of CAP which was based on the presence of select clinical features eg cough fever sputum production and pleuritic chest pain and is supported by imaging of the lung usually by chest radiography according to Infectious Diseases Society of AmericaAmerican Thoracic Society consensus guidelines on the management of CAP in adults 11
CAP is not considered if the patient is discharged from a hospital less than 7 days before the current hospital admission if the first blood culture or urinary antigen assay is obtained more than 1 week after hospital admission or if the patient has no clinical diagnosis of CAP at the time of admission Patients referred from or transferred to another hospital are excluded
After identification of eligible patients upon microbiological results medical records are reviewed using a standardized data collection questionnaire Comorbidity is determined using the Charlson comorbidity index 10 Additionally all patients are classified according to the multimorbidity patterns proposed by Holden et al 12 These are
1 arthritis osteoporosis other chronic pain bladder problems and irritable bowel
2 asthma chronic obstructive pulmonary disease and allergies
3 backneck pain migraine other chronic pain and arthritis
4 high blood pressure high cholesterol obesity diabetes and fatigue
5 cardiovascular disease diabetes fatigue high blood pressure high cholesterol and arthritis and
6 irritable bowel ulcer heartburn and other chronic pain
Time calculation is based upon the moment of emergency room ER admission
CAP is not considered if the patient is discharged from a hospital less than 7 days before the current hospital admission if the first blood culture or urinary antigen assay is obtained more than 1 week after hospital admission or if the patient has no clinical diagnosis of CAP at the time of admission Patients referred from or transferred to another hospital are excluded
After identification of eligible patients upon microbiological results medical records are reviewed using a standardized data collection questionnaire Comorbidity is determined using the Charlson comorbidity index 10 Additionally all patients are classified according to the multimorbidity patterns proposed by Holden et al 12 These are
1 arthritis osteoporosis other chronic pain bladder problems and irritable bowel
2 asthma chronic obstructive pulmonary disease and allergies
3 backneck pain migraine other chronic pain and arthritis
4 high blood pressure high cholesterol obesity diabetes and fatigue
5 cardiovascular disease diabetes fatigue high blood pressure high cholesterol and arthritis and
6 irritable bowel ulcer heartburn and other chronic pain
Time calculation is based upon the moment of emergency room ER admission
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None