Ignite Creation Date:
2024-05-06 @ 12:54 AM
Last Modification Date:
2024-10-26 @ 10:56 AM
Study NCT ID:
NCT01682915
Status:
COMPLETED
Last Update Posted:
2021-09-02
First Post:
2012-09-07
Brief Title:
Structural and Functional Connectivity of Frontostriatal and Frontoparietal Networks as Endophenotypes of ADHD
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Structural and Functional Connectivity of Frontostriatal and Frontoparietal Networks as Endophenotypes of Attention-deficit Hyperactivity Disorder
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Attention deficithyperactivity disorder ADHD is a common impairing clinically and genetically heterogeneous neuropsychiatric disorder with lifelong executive dysfunctions The ultimate goal of this 3-year case-control imaging genomic study with unaffected siblings and typically developing TD children as controls is to identify useful imaging endophenotype for ADHD by investigating the structural connectivity as assessed by diffusion spectrum imaging DSI and functional connectivity as assessed by resting-state fMRI rsfMRI of brain regions related to cognitiveexecutive controls with regards to the ADHD status and the presence of dopamine transporter gene variants DAT1
Specific Aims
1 to validate the executive functions visuospatial memory and structural and functional connectivity in frontostriatal and frontoparietal circuitries as effective neurocognitive endophenotypes
2 to correlate the data from structural and functional connectivity neuropsychology and ADHD core symptoms stratifying by the presence of ADHD proband-unaffected sibling dyads and the presence of DAT1 variant and
3 To investigate reported candidate genes in addition to DAT1 variant related to dopamine and noradrenergic neurotransmitter systems in the association with neurocognitive endophenotypes such as DRD1 DRD2 DRD4 DRD5 DBH MAO-A ADRA2A ADRA2C NET and COMT
Specific Aims
1 to validate the executive functions visuospatial memory and structural and functional connectivity in frontostriatal and frontoparietal circuitries as effective neurocognitive endophenotypes
2 to correlate the data from structural and functional connectivity neuropsychology and ADHD core symptoms stratifying by the presence of ADHD proband-unaffected sibling dyads and the presence of DAT1 variant and
3 To investigate reported candidate genes in addition to DAT1 variant related to dopamine and noradrenergic neurotransmitter systems in the association with neurocognitive endophenotypes such as DRD1 DRD2 DRD4 DRD5 DBH MAO-A ADRA2A ADRA2C NET and COMT
Detailed Description:
The sample n240 8 groups ages 10-20 IQ 80 consists of 1 30 ADHD probands with DAT1 variants 2 30 same-sex unaffected siblings 3 30 ADHD probands without DAT1 gene variants who were age- sex- and IQ-matched to Group 1 4 30 same-sex unaffected siblings of Group 3 5 30 age- sex- and IQ-matched TD controls for each of 4 groups Groups 1 2 3 4
The assessments include psychiatric interviews self-administered questionnaires CBCL and SNAP-IV for ADHD and behavioral problems the SAICA for school and social function neurocognitive assessments WISC-III-R or WAIS-III for intelligence Conners CPT for sustained attention inhibition and vigilance CANTAB for executive functions and visuo-spatial memory and MRI assessments Structural MRI DSI and rsfMRI
Brain Imaging 1 Structural MRI T1- and T2-weighted images DSI and rsfMRI data will be acquired on a 3T MRI system with a 32-channel head coil DSI employs a pulsed-gradient spin-echo echo planar imaging EPI sequence by applying 102 diffusion gradient vectors and the maximum diffusion sensitivity 4000 smm2 and rsfMRI is a 6-minute scan using a gradient-echo EPI sequence with 180 volumes 2 Structural connectivity analysis DSI tractography will be performed using in-house software DSI studio httpdsi-studiolabsolverorgHome Tracts-of-interest in the frontostriatal circuit and the frontoparietal circuit will be identified and tract-specific analysis will be used to analyze the microstructural integrity along individual tract bundles 3 Functional connectivity analysis SPM8 program and in-house MATLAB codes will be used for analyses of rsfMRI data Region-of-interests ROIs will be placed in the nodes of the corresponding circuits according to an anatomical template WFU_PickAtlas 303 These ROIs will serve for tract determination in the tractography procedure and for seed regions in which BOLD signals are extracted for regression analysis among nodes
The assessments include psychiatric interviews self-administered questionnaires CBCL and SNAP-IV for ADHD and behavioral problems the SAICA for school and social function neurocognitive assessments WISC-III-R or WAIS-III for intelligence Conners CPT for sustained attention inhibition and vigilance CANTAB for executive functions and visuo-spatial memory and MRI assessments Structural MRI DSI and rsfMRI
Brain Imaging 1 Structural MRI T1- and T2-weighted images DSI and rsfMRI data will be acquired on a 3T MRI system with a 32-channel head coil DSI employs a pulsed-gradient spin-echo echo planar imaging EPI sequence by applying 102 diffusion gradient vectors and the maximum diffusion sensitivity 4000 smm2 and rsfMRI is a 6-minute scan using a gradient-echo EPI sequence with 180 volumes 2 Structural connectivity analysis DSI tractography will be performed using in-house software DSI studio httpdsi-studiolabsolverorgHome Tracts-of-interest in the frontostriatal circuit and the frontoparietal circuit will be identified and tract-specific analysis will be used to analyze the microstructural integrity along individual tract bundles 3 Functional connectivity analysis SPM8 program and in-house MATLAB codes will be used for analyses of rsfMRI data Region-of-interests ROIs will be placed in the nodes of the corresponding circuits according to an anatomical template WFU_PickAtlas 303 These ROIs will serve for tract determination in the tractography procedure and for seed regions in which BOLD signals are extracted for regression analysis among nodes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None