Ignite Creation Date:
2024-05-06 @ 12:53 AM
Last Modification Date:
2024-10-26 @ 10:56 AM
Study NCT ID:
NCT01686269
Status:
UNKNOWN
Last Update Posted:
2012-09-18
First Post:
2009-02-06
Brief Title:
Endothelial Progenitor Cells
Sponsor:
Far Eastern Memorial Hospital
Organization:
Far Eastern Memorial Hospital
Study Overview
Official Title:
Mobilization of Endothelial Progenitor Cells in Patients With Coronary Artery Bypass Surgery
Status:
UNKNOWN
Status Verified Date:
2007-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Vascular stenosis as a result of neointimal hyperplasia is a major clinical problem that has an impact on multiple and diverse disciplines including cardiology coronary restenosis cardiothoracic and vascular surgery saphenous vein and polytetrafluoroethylene PTFE graft failure neurology carotid stenosis nephrology dialysis access dysfunction and transplant medicine chronic allograft rejection in hearts and kidneys 1 In marked contrast to the deleterious effects of smooth muscle progenitor cells on neointimal hyperplasia circulating endothelial progenitor cells EPCs are believed to play an important role in vascular repair and in the inhibition of neointimal hyperplasia 2 Endothelial progenitor cells EPCs circulate in adult peripheral blood and contribute to neovascularization Satoshi et al have demonstrated that lineage-committed EPCs and CD34-positive mononuclear cells their putative precursors are mobilized during an acute ischemic event in humans 3 Reduced levels of circulating EPCs independently predict atherosclerotic disease progression thus supporting an important role for endogenous vascular repair to modulate the clinical course of coronary artery disease 4 These observations prompt the hypothesis that circulating EPCs may provide an endogenous repair mechanism to counteract surgery-induced endothelial cell injury and to replace dysfunctional endothelium perioperatively Therefore the investigators examined whether levels of circulating EPCs correlate with time course and outcomes of coronary artery bypass surgery to establish a clinical role of endogenous endothelial repair mediated by circulating EPCs
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None