Ignite Creation Date:
2025-12-25 @ 3:47 AM
Ignite Modification Date:
2026-01-08 @ 10:40 PM
Study NCT ID:
NCT06513702
Status:
NOT_YET_RECRUITING
Last Update Posted:
2024-07-22
First Post:
2024-07-16
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
To Determine the Effectiveness of Transesophageal Lung Ultrasound Guided Recruitment Maneuver in Cardiac Surgery
Sponsor:
University of Malaya
Organization:
Study Overview
Official Title:
The Effectiveness of Transesophageal Lung Ultrasound (TELUS) Guided Recruitment Maneuver to Reduce Lung Atelectasis After Cardiac Surgery: a Randomized Controlled Trial
Status:
NOT_YET_RECRUITING
Status Verified Date:
2024-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
TELUS-REM
Brief Summary:
This study is to evaluate the effectiveness of Transesophageal Lung ULtrasound (TELUS) guided recruitment maneuver to reduce lung atelelectasis in cardiac surgery. This is a RCT trial involving a cardiac patient that requiring used of cardiopulmonary bypass machine intraoperatively. These patient will be randomized into either intervention group or control group.
Detailed Description:
Post operative pulmonary complications is a common cause of morbidity and mortality in cardiac surgery. Lung atelectasis (collapse) contributes to dysfunctional of right ventricular performance post cardiac surgery, due to increase impedance in right ventricular outflow tract. Recruitment (Lung re-expansion) maneuver is proven to be effective to reverse this effect, however it is not routinely done intraoperatively. In this study , we are conducting a randomized controlled trial to evaluate effectiveness of transesophageal lung ultrasound (TELUS) guided recruitment maneuver to reduce incidence of lung atelectasis in cardiac surgery. By this intervention, we hope that it will lead to reduce the incidence of postoperative pulmonary complications after undergoing cardiopulmonary bypass surgery.
This is a single center,prospective, a randomized controlled trial (RCT) study in cardiac surgery patient.
Patient will be randomized into 2 groups after consented into this study. After the operating list has been confirmed, we will visit the patients to be recruited, explain the purposes of this study, and then offer them to participate in this study. If the patients agree to participate in this study, they will need to sign a consent form in Malay or English language. Each participant will be assigned a code number to protect their confidentiality and the code number will be written clearly on an opaque envelope. The opaque envelope will contain participant's consent form, patient information sheet, and data collection sheet. Patient will be randomized by computer generated system into control group (group C) and recruitment maneuver group (group RM).
On the day of operation, the operation will be proceeded under general anesthesia as per standard practice. Induction and maintenance of anesthesia will be conducted as per standard practice.
Standard arterial and central venous catheterization will be inserted in all patients. The operation will be proceeded as per usual practice. The patient will be put on cardiopulmonary bypass (CBP) machine as per usual practice and the operation will be done as per scheduled. Mechanical ventilator will be suspended during CBP. Once CBP was disconnected, lung will be reinflated by giving five deep manual bag insufflations until full lung expansion observed by anaesthetist, however in interventional group lung inflation is guided by transesophageal lung ultrasound. During sternal wiring approximately about 30 minutes before the end of surgery, in interventional group they will receive a lung recruitment maneuver by continuous CPAP at 30cmH2o for 20seconds followed by PEEP 0f 8cmH20. In both groups, lung ultrasound and heart ultrasound (TOE) will be done to evaluate lung and heart function. Further assessment will be done in RM group with lung and heart ultrasound to look for changes after lung recruitment maneuver. If there is still evidence of lung collapse in the second assessment, repeated lung recruitment maneuver will be done with continuous CPAP at 40cmh20 for 20 seconds. The lung recruitment maneuver will be immediately stopped if there were signs of hypovolaemia, impairment in right ventricular contraction or a change at least 15% of baseline MAP and HR or desaturation.
Once operation is completed, patients will be reassessed again by heart ultrasound. The patient then will be transferred to the Cardiac Intensive Care Unit (CICU). The patient will be wean off from mechanical ventilator once condition permitted.
After surgery, the investigator will assess patients daily to obtain the clinical data. The patient then will be continued to be follow up until the day of discharge from hospital.
This is a single center,prospective, a randomized controlled trial (RCT) study in cardiac surgery patient.
Patient will be randomized into 2 groups after consented into this study. After the operating list has been confirmed, we will visit the patients to be recruited, explain the purposes of this study, and then offer them to participate in this study. If the patients agree to participate in this study, they will need to sign a consent form in Malay or English language. Each participant will be assigned a code number to protect their confidentiality and the code number will be written clearly on an opaque envelope. The opaque envelope will contain participant's consent form, patient information sheet, and data collection sheet. Patient will be randomized by computer generated system into control group (group C) and recruitment maneuver group (group RM).
On the day of operation, the operation will be proceeded under general anesthesia as per standard practice. Induction and maintenance of anesthesia will be conducted as per standard practice.
Standard arterial and central venous catheterization will be inserted in all patients. The operation will be proceeded as per usual practice. The patient will be put on cardiopulmonary bypass (CBP) machine as per usual practice and the operation will be done as per scheduled. Mechanical ventilator will be suspended during CBP. Once CBP was disconnected, lung will be reinflated by giving five deep manual bag insufflations until full lung expansion observed by anaesthetist, however in interventional group lung inflation is guided by transesophageal lung ultrasound. During sternal wiring approximately about 30 minutes before the end of surgery, in interventional group they will receive a lung recruitment maneuver by continuous CPAP at 30cmH2o for 20seconds followed by PEEP 0f 8cmH20. In both groups, lung ultrasound and heart ultrasound (TOE) will be done to evaluate lung and heart function. Further assessment will be done in RM group with lung and heart ultrasound to look for changes after lung recruitment maneuver. If there is still evidence of lung collapse in the second assessment, repeated lung recruitment maneuver will be done with continuous CPAP at 40cmh20 for 20 seconds. The lung recruitment maneuver will be immediately stopped if there were signs of hypovolaemia, impairment in right ventricular contraction or a change at least 15% of baseline MAP and HR or desaturation.
Once operation is completed, patients will be reassessed again by heart ultrasound. The patient then will be transferred to the Cardiac Intensive Care Unit (CICU). The patient will be wean off from mechanical ventilator once condition permitted.
After surgery, the investigator will assess patients daily to obtain the clinical data. The patient then will be continued to be follow up until the day of discharge from hospital.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: