Ignite Creation Date:
2024-05-06 @ 12:50 AM
Last Modification Date:
2024-10-26 @ 10:56 AM
Study NCT ID:
NCT01678521
Status:
COMPLETED
Last Update Posted:
2014-12-19
First Post:
2012-08-24
Brief Title:
Effect of LDL-apheresis on PTX3 Plasma Levels in Hypercholesterolemic Patients
Sponsor:
Universita di Verona
Organization:
Universita di Verona
Study Overview
Official Title:
Effect of LDL-apheresis on Pentraxin3 Plasma Levels in Hypercholesterolemic Patients With Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2014-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Inflammation plays a major role in atherosclerosis Pentraxin 3 PTX3 a multifunctional pattern-recognition protein is expressed in many tissuescells including innate immunity cells endothelium and atherosclerotic plaques Its role is controversial it may exert protective cardiovascular effects andor it may be an indicator of plaque vulnerability and future cardiovascular risk
LDL-Apheresis removes apoB100-containing lipoproteins and it can prevent progression of coronary artery disease CAD LDL-Apheresis exerts non-lipidic beneficial effects on the procoagulatory state and on hemorheology No data exist about the effects of LDL-Apheresis on plasma PTX3 levels
LDL-Apheresis removes apoB100-containing lipoproteins and it can prevent progression of coronary artery disease CAD LDL-Apheresis exerts non-lipidic beneficial effects on the procoagulatory state and on hemorheology No data exist about the effects of LDL-Apheresis on plasma PTX3 levels
Detailed Description:
Hypercholesterolemic patients with documented CAD on chronic fortnightly LDL-apheresis treatment will be enrolled in this study
Blood samples will be collected before and after a single LDL-Apheresis treatment to asses PTX3 HsCRP IL6 IL10 Fibrinogen and lipid plasma levels
Blood samples will be collected before and after a single LDL-Apheresis treatment to asses PTX3 HsCRP IL6 IL10 Fibrinogen and lipid plasma levels
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None