Ignite Creation Date:
2024-05-06 @ 12:50 AM
Last Modification Date:
2024-10-26 @ 10:55 AM
Study NCT ID:
NCT01665833
Status:
COMPLETED
Last Update Posted:
2012-08-15
First Post:
2012-08-13
Brief Title:
Impact of Coronary Anatomy on Angina Relief in Patients Undergoing Coronary Revascularization
Sponsor:
North Texas Veterans Healthcare System
Organization:
North Texas Veterans Healthcare System
Study Overview
Official Title:
A Retrospective Analysis Determining the Impact of Coronary Anatomy on Angina Relief in Patients Undergoing Coronary
Status:
COMPLETED
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
We hypothesize that Coronary Artery Disease CAD severity assessed by SYNTAX score is an independent predictor of recurrent or persistent angina following coronary revascularization The SYNTAX score is a score that suggests the severity of coronary artery disease detected by coronary angiography Coronary revascularization is a procedure that occurs in two ways a percutaneous coronary intervention PCI and a coronary artery bypass graft CABG and is done when there is narrowing and blockage or hardening of the arteries atherosclerosis surrounding the heart Narrowing and blockages reduce blood flow to parts of the heart causing chest pain known as angina and sometimes myocardial infarction
Detailed Description:
PCI and CABG are two well-established revascularization approaches to treatment of chronic angina caused by coronary atherosclerosis Nevertheless 35-42 of patients report recurring or persisting anginal symptoms after coronary revascularization This can be attributed to many structural and functional causes prominent amongst which is pre-revascularization angina severity unrevascularized coronary territory progression of native or bypass graft atherosclerosis restenosis re-narrowing of the vessels and accompanying adjunctive pharmacotherapy
The SYNTAX score is an angiographic tool for grading the complexity of coronary disease It is the sum of points assigned to coronary lesions within one of the 16 segments of the coronary tree The segments are given a 12 or 5 based on the disease presence as defined by the American Heart Association classification The SYNTAX score has been used to help predict the outcomes of patients undergoing PCI with 3-vessel involvement eg a triple bypass or 3-stent placement PCI Those patients with the highest scores had the highest risk of a poor outcome with PCI revascularization compared to CABG Despite these observations the impact of CAD severity on post-revascularization angina using the SYNTAX has never been systematically addressed in the current era
The SYNTAX score is an angiographic tool for grading the complexity of coronary disease It is the sum of points assigned to coronary lesions within one of the 16 segments of the coronary tree The segments are given a 12 or 5 based on the disease presence as defined by the American Heart Association classification The SYNTAX score has been used to help predict the outcomes of patients undergoing PCI with 3-vessel involvement eg a triple bypass or 3-stent placement PCI Those patients with the highest scores had the highest risk of a poor outcome with PCI revascularization compared to CABG Despite these observations the impact of CAD severity on post-revascularization angina using the SYNTAX has never been systematically addressed in the current era
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None