Ignite Creation Date:
2024-05-06 @ 12:49 AM
Last Modification Date:
2024-10-26 @ 10:55 AM
Study NCT ID:
NCT01665300
Status:
COMPLETED
Last Update Posted:
2014-04-29
First Post:
2011-12-13
Brief Title:
Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
Sponsor:
Seoul National University Hospital
Organization:
Seoul National University Hospital
Study Overview
Official Title:
Usefulness of Myocardial Deformation Imaging in Breast Cancer Patients Treated With Trastuzumab for Early Detection of Myocardial Dysfunction
Status:
COMPLETED
Status Verified Date:
2014-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer Sequential left ventricular LV ejection fraction EF assessment has been mandated to detect myocardial dysfunction because of the risk of heart failure with this treatment Myocardial deformation imaging is a sensitive means of detecting LV dysfunction but this technique has not been evaluated in patients treated with trastuzumab The aim of this study was to investigate whether changes in tissue deformation assessed by myocardial strain and strain rate SR are able to identify LV dysfunction earlier than conventional echocardiographic measures in patients treated with trastuzumab
Detailed Description:
The investigators will prospectively evaluate whether changes in tissue deformation assessed by myocardial strain and strain rate SR and identify possibility of early detection of LV dysfunction in patients treated with trastuzumab
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None