Ignite Creation Date:
2024-05-06 @ 12:48 AM
Last Modification Date:
2024-10-26 @ 10:55 AM
Study NCT ID:
NCT01667523
Status:
COMPLETED
Last Update Posted:
2012-08-17
First Post:
2011-04-12
Brief Title:
The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability Gallbladder Motility and Satiety
Status:
COMPLETED
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
An altered permeability has been proposed to play an important role in the pathogenesis of several gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease Nutrients derived from food are able to influence the permeability of the intestine and can therefore also affect gastrointestinal symptoms In this study the investigators will investigate the effects of capsaicine and cinnamaldehyde which can be found in hot peppers and cinnamon respectively on gastrointestinal physiology
Objective
To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine these substances will be infused directly in the duodenum Hereafter the permeability of the intestine gallbladder motility and the effects on satiety will be assessed
Hypothesis
Duodenal capsaicin and cinnamaldehyde infusion induces changes in the intestinal epithelial barrier function by selectively acting on TRPV1 and TRPA1 receptors and releasing serotonin from enterochromaffin cells as determined by the multi sugar permeability test
Objective
To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine these substances will be infused directly in the duodenum Hereafter the permeability of the intestine gallbladder motility and the effects on satiety will be assessed
Hypothesis
Duodenal capsaicin and cinnamaldehyde infusion induces changes in the intestinal epithelial barrier function by selectively acting on TRPV1 and TRPA1 receptors and releasing serotonin from enterochromaffin cells as determined by the multi sugar permeability test
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None