Ignite Creation Date:
2024-05-06 @ 12:48 AM
Last Modification Date:
2024-10-26 @ 10:55 AM
Study NCT ID:
NCT01660594
Status:
COMPLETED
Last Update Posted:
2012-08-09
First Post:
2012-08-06
Brief Title:
CT Calcium Scoring in Suspected Stable Angina
Sponsor:
Royal Brompton Harefield NHS Foundation Trust
Organization:
Royal Brompton Harefield NHS Foundation Trust
Study Overview
Official Title:
Comparison of CT Coronary Artery Calcium Scoring With Traditional Assessment in Patients Presenting to the Rapid Access Chest Pain Clinic With Non-acute Chest Pain and Its Prognostic Value
Status:
COMPLETED
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Patients with stable chest pain presenting to general practitioners in UK are routinely referred to the chest pain clinics in the hospitals They are assessed by clinical history including risk factors cardiovascular exam resting ECG chest x-ray and exercise ECG CT calcium scoring CTCS is a technique that is very sensitive in identifying and quantifying calcified atherosclerotic plaques Recent guidance from the National Institute of Clinical Excellence NICE citation 1 proposes the use of CTCS in patients with stable chest pain who have low likelihood of coronary artery disease CAD They recommend that patients with low likelihood 10-30 have a CTCS and if the score is 0 they can be considered to have non-cardiac chest pain However there is controversy regarding relationship of absent calcification with significant CAD and its prognostic value
At our institution we have been performing CTCS in this patient cohort since 2003 We plan to retrospectively review the usefulness in CTCS in patients with different likelihood for significant CAD particularly in patients with absent calcium and compare with the traditional assessment We also plan to follow-up these patients for any myocardial infarction and death from any cause
At our institution we have been performing CTCS in this patient cohort since 2003 We plan to retrospectively review the usefulness in CTCS in patients with different likelihood for significant CAD particularly in patients with absent calcium and compare with the traditional assessment We also plan to follow-up these patients for any myocardial infarction and death from any cause
Detailed Description:
The study seeks to determine the usefulness of CT calcium scoring CTCS in patients presenting with non-acute chest pain to the rapid access chest pain clinic RACPC and compare it with the traditional assessment in predicting significant CAD and outcome with respect to non-fatal MI or death The clinical diagnostic and follow-up data of patients in last 7 years since CTCS has been performed in the hospital would be retrospectively analysed for the purpose
Background Patients with chest pain excluding that of sudden onset are routinely referred by the GPs to the RACPC centres in the hospitals They are assessed by clinical history including risk factors cardiovascular exam resting ECG chest x-ray and exercise ECG At our institution we have also been performing CTCS in men more than 40 and women more than 50 years of age since 2003 Recent NICE guidance1 recommends that patients with low pre-test probability 10-30 of significant coronary artery disease CAD have a CT calcium scoring scan and if the score is 0 they can be considered to have non-cardiac chest pain However there is controversy regarding relationship of absent calcification with significant CAD and its prognostic value
This study would enable us to compare and determine the value of CTCS in patients with non-acute chest pain in predicting significant CAD and safety of absent coronary artery calcification
Rationale for Study
1 To determine if CT coronary calcium scoring adds any value to the existing clinical assessment and exercise ECG This is not well established in patients presenting with non-acute chest pain to the rapid access chest pain clinics
2 The study would help in determining if absence of calcification on CT can be considered to have low likelihood of significant coronary artery disease and a good cardiovascular outcome over the period of follow-up Both these issues are currently controversial in the literature in this group of patients
STUDY OBJECTIVES
Primary Objective To determine the prognostic value of CT coronary calcium scoring in patients with non-acute chest pain for non-fatal MI and death and compare with traditional assessment including exercise ECG
Secondary Objectives To determine how CT coronary calcium scoring compare with traditional assessment including exercise ECG in predicting significant coronary artery disease in patients presenting with non-acute chest pain
METHODOLOGY Design This is a retrospective cross-sectional study involving analysis of patients clinical diagnostic and management data from hospital records and follow-up questionnaires for outcome The study does not require any new diagnostic therapeutic or interventional procedure
Data of patients who have presented to the chest pain clinic since October 2003 would be collected from hospital records for
1 Age sex type of chest pain and risk factors These would be used to calculate the pre-test probability of significant coronary artery disease CAD using Dukes score
2 Results of exercise ECG where performed
3 Results of CT calcium scoring
4 Results of other non-invasive investigations such as stress imaging and CT coronary angiography where performed
5 Results of invasive coronary angiography where performed Patients with 70 diameter stenosis or those who underwent percutaneous stent insertion PCI or bypass surgery would be considered to have significant CAD
For those patients who do not undergo any PCI or surgery as a result of above evaluation we will try to find out if they have subsequently suffered any heart attack or died This would again be performed through hospital records and if not available through questionnaires send to the patients andor their GPs as part of standard clinical care
Background Patients with chest pain excluding that of sudden onset are routinely referred by the GPs to the RACPC centres in the hospitals They are assessed by clinical history including risk factors cardiovascular exam resting ECG chest x-ray and exercise ECG At our institution we have also been performing CTCS in men more than 40 and women more than 50 years of age since 2003 Recent NICE guidance1 recommends that patients with low pre-test probability 10-30 of significant coronary artery disease CAD have a CT calcium scoring scan and if the score is 0 they can be considered to have non-cardiac chest pain However there is controversy regarding relationship of absent calcification with significant CAD and its prognostic value
This study would enable us to compare and determine the value of CTCS in patients with non-acute chest pain in predicting significant CAD and safety of absent coronary artery calcification
Rationale for Study
1 To determine if CT coronary calcium scoring adds any value to the existing clinical assessment and exercise ECG This is not well established in patients presenting with non-acute chest pain to the rapid access chest pain clinics
2 The study would help in determining if absence of calcification on CT can be considered to have low likelihood of significant coronary artery disease and a good cardiovascular outcome over the period of follow-up Both these issues are currently controversial in the literature in this group of patients
STUDY OBJECTIVES
Primary Objective To determine the prognostic value of CT coronary calcium scoring in patients with non-acute chest pain for non-fatal MI and death and compare with traditional assessment including exercise ECG
Secondary Objectives To determine how CT coronary calcium scoring compare with traditional assessment including exercise ECG in predicting significant coronary artery disease in patients presenting with non-acute chest pain
METHODOLOGY Design This is a retrospective cross-sectional study involving analysis of patients clinical diagnostic and management data from hospital records and follow-up questionnaires for outcome The study does not require any new diagnostic therapeutic or interventional procedure
Data of patients who have presented to the chest pain clinic since October 2003 would be collected from hospital records for
1 Age sex type of chest pain and risk factors These would be used to calculate the pre-test probability of significant coronary artery disease CAD using Dukes score
2 Results of exercise ECG where performed
3 Results of CT calcium scoring
4 Results of other non-invasive investigations such as stress imaging and CT coronary angiography where performed
5 Results of invasive coronary angiography where performed Patients with 70 diameter stenosis or those who underwent percutaneous stent insertion PCI or bypass surgery would be considered to have significant CAD
For those patients who do not undergo any PCI or surgery as a result of above evaluation we will try to find out if they have subsequently suffered any heart attack or died This would again be performed through hospital records and if not available through questionnaires send to the patients andor their GPs as part of standard clinical care
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None