Ignite Creation Date:
2024-05-06 @ 12:48 AM
Last Modification Date:
2024-10-26 @ 10:55 AM
Study NCT ID:
NCT01664962
Status:
COMPLETED
Last Update Posted:
2012-08-14
First Post:
2012-08-09
Brief Title:
Search for Genetic Basis of Vulvodynia
Sponsor:
Western Galilee Hospital-Nahariya
Organization:
Western Galilee Hospital-Nahariya
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to investigate the possibility of an association between Localized Provoked Vulvodynia LPV that is both severe and primary and polymorphic markerssingle nucleotide polymorphisms SNPs in and around the genes encoding heparanase HSPE-1 Vanilloid Receptor VR1 TRPV1 and Nerve Growth Factor NGF
Detailed Description:
The short-term goal proposed for the current study was to investigate the possibility of an association between Localized Provoked Vulvodynia LPV that is both severe and primary and polymorphic markerssingle nucleotide polymorphisms SNPs in and around the genes encoding heparanase HSPE-1 Vanilloid Receptor VR1 TRPV1 and Nerve Growth Factor NGF
Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow
1 HSPE gene Four polymorphic SNPs rs4693608 rs11099592 rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population
2 TRPV1 gene Two polymorphic SNPs rs222747 and rs8065080
3 NGF gene A novel T to C SNP in the promoter region at position -198 rs11102930 and rs6330 which was found to be associated with anxiety-related personality traits and has been suggested to may affect intracellular processing and secretion of NGF
Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow
1 HSPE gene Four polymorphic SNPs rs4693608 rs11099592 rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population
2 TRPV1 gene Two polymorphic SNPs rs222747 and rs8065080
3 NGF gene A novel T to C SNP in the promoter region at position -198 rs11102930 and rs6330 which was found to be associated with anxiety-related personality traits and has been suggested to may affect intracellular processing and secretion of NGF
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None