Ignite Creation Date:
2024-05-06 @ 12:46 AM
Last Modification Date:
2024-10-26 @ 10:54 AM
Study NCT ID:
NCT01651429
Status:
COMPLETED
Last Update Posted:
2014-06-16
First Post:
2012-07-23
Brief Title:
Predicting Cognitive Resilience Against Sleep Loss
Sponsor:
Mclean Hospital
Organization:
Mclean Hospital
Study Overview
Official Title:
Multimodal Neuroimaging to Predict Cognitive Resilience Against Sleep Loss
Status:
COMPLETED
Status Verified Date:
2014-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Resilience is the ability to cope effectively and adapt to a wide range of stressful environmental challenges Sleep loss has been shown to reduce activity in the brain regions responsible for resilience The ability to resist the effects of sleep loss appears to be a stable trait-like quality This study will attempt to predict individuals trait-resistance to sleep loss based on their neurobiology
Detailed Description:
Resilience the ability to cope effectively and adapt to a wide range of stressful environmental challenges appears to be mediated extensively by the medial prefrontal cortex MPFC Sleep deprivation has been shown to reduce metabolic activity throughout the brain particularly the MPFC The ability to resist the effects of sleep loss appears to be a stable trait-like phenomenon that is consistent across situations suggesting that it may reflect an enduring quality of the underlying neurobiological system The present study aims to identify the neural basis of resilience and effectively discriminate resistant from vulnerable individuals during an overnight sleep deprivation session Specifically the primary aims of this research are 1 to further our understanding of the role of the MPFC in resilience and 2 to develop a statistical prediction algorithm based on multimodal neuroimaging that will reliably discriminate between individuals who are resilient versus vulnerable to the cognitive impairing effects of sleep loss
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None