Ignite Creation Date:
2025-12-25 @ 3:31 AM
Ignite Modification Date:
2025-12-26 @ 2:13 AM
Study NCT ID:
NCT01606605
Status:
COMPLETED
Last Update Posted:
2013-01-15
First Post:
2012-05-22
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Treatment Resistance Related With Gene Expression Profile of Diffuse Large B-cell Lymphoma
Sponsor:
Samsung Medical Center
Organization:
Study Overview
Official Title:
Retrospective Analysis of Diffuse Large B-cell Lymphoma: Identification of Factors Associated With Treatment Resistance Via Gene Expression Profile
Status:
COMPLETED
Status Verified Date:
2013-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.
Detailed Description:
1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay
* Diffuse large B-cell lymphoma patients
* Paraffin-embedded tissue
* End points: Progression-free survival, overall survival
* Statistics: Leave one-out method
2. Nano string assay for microRNA
* Diffuse large B-cell lymphoma patients
* Paraffin-embedded tissue
* End points: Progression-free survival, overall survival
* Statistics: Leave one-out method
* Diffuse large B-cell lymphoma patients
* Paraffin-embedded tissue
* End points: Progression-free survival, overall survival
* Statistics: Leave one-out method
2. Nano string assay for microRNA
* Diffuse large B-cell lymphoma patients
* Paraffin-embedded tissue
* End points: Progression-free survival, overall survival
* Statistics: Leave one-out method
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: