Ignite Creation Date:
2024-05-06 @ 12:40 AM
Last Modification Date:
2024-10-26 @ 10:53 AM
Study NCT ID:
NCT01634737
Status:
COMPLETED
Last Update Posted:
2014-03-07
First Post:
2012-07-03
Brief Title:
Crustacean Allergy and Dust Mites Sensitization
Sponsor:
Niguarda Hospital
Organization:
Niguarda Hospital
Study Overview
Official Title:
Crustacean Allergy and Sensitization to Dust Mites in Patients With Respiratory Allergy Clinical Study and Analysis of Common and Peculiar Allergens
Status:
COMPLETED
Status Verified Date:
2014-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study evaluates the diagnostic efficacy of CAP System capsulated hydrophilic carrier polymer for recombinant tropomyosin from shrimp extract in discriminating between subjects allergic to shrimp with CAP positive subjects allergic to mites crustaceans asymptomatic but with a positive CAP to shrimp to identify those at greatest risk of food reactions
Detailed Description:
Most epidemiological data related to allergy to shellfish come from the USA where 25 of the adult population is subject to an allergy to shellfish which is also the leading cause of anaphylaxis in adults in these areas This allergy affects also the European adult population so that the crustaceans were included in the European Directive 200389EC on the labeling requirement to indicate any allergenic ingredients listed in Annex 3 a used in the production of a food and present although in other form in the finished product The allergen mainly involved in allergic reactions to shellfish food is the tropomyosin protein of PM of about 34-36 kDa isolated for the first time in the shrimp Pen to 1 involved in the mechanisms of muscle activation and identified in the muscle fiber of many crustaceans Pen i 1 Cha f 1 Cra c 1 Hom a 1 v 1 Lit Pan s 1 Pen m 1 and molluscs Hel as 1 d 1 Hal Cra g 1 Oct 1 st Tod p 1 The tropomyosins identified in many other invertebrates such as dust mites and cockroaches seem to be cross-reactive with each other suggesting the role of allergens inside of the Invertebrates In those circumstances the positivity of specific IgE for the crustaceans can thus be determined also by sensitization to tropomyosin even for simple cross-reactivity with tropomyosin of the mites which represents a minor allergen Der known as p10
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None