Ignite Creation Date:
2024-05-06 @ 12:36 AM
Last Modification Date:
2024-10-26 @ 10:52 AM
Study NCT ID:
NCT01619501
Status:
UNKNOWN
Last Update Posted:
2013-12-11
First Post:
2012-04-04
Brief Title:
Dysregulation of the CEBPa Pathway in Human Lung Cancer and Search for New Biomarkers andor Therapeutic Targets
Sponsor:
National University Hospital Singapore
Organization:
National University Hospital Singapore
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2013-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The overall goal of this research is to enhance the investigators understanding of the pathways involved in lung cancer and to identify new biomarkers andor therapeutic targets By comparing gene expression between normal lung tissue and tumors growing in lung-specific CEBPa KO mice the investigators have identified the Bmi-1 proto-oncogene as being abnormally upregulated in CEBPa-deleted tumors Subsequently the investigators have validated this observation in human lung cancer implicating the investigators KO mice are an effective discovery tool for lung cancer research Through similar approaches the investigators have already identified Sonic Hedgehog SHH and plan to identify other pathways which are abnormally regulated in CEBPa-- tumors In parallel the investigators will proceed to define the clinical relevance of the SHH pathway and the other newly-discovered molecular aberrations by analyzing their expression and correlate it to CEBPa expression on the samples of patients with NSCLC at NUHS If the investigators preliminary data on Bmi-1 will be confirmed this proto-oncogene may generate useful correlates that could be used in diagnosis and treatment of lung cancer as well as identify new prognosticpredictive markers in lung cancer Similarly SHH pathway-components may behave as potential biomarkers and therapeutic tools for CEBPa-related lung cancers
This proposal seeks to test the hypothesis that pathways which are dysregulated in lung tumors growing in a lung-specific CEBPa KO model can be utilized as discovery tools to identify genes involved in human lung cancer pathogenesis
This proposal seeks to test the hypothesis that pathways which are dysregulated in lung tumors growing in a lung-specific CEBPa KO model can be utilized as discovery tools to identify genes involved in human lung cancer pathogenesis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None