Ignite Creation Date:
2024-05-05 @ 11:41 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00106470
Status:
COMPLETED
Last Update Posted:
2012-12-17
First Post:
2005-03-24
Brief Title:
Genetic Factors That Influence Chronic Obstructive Pulmonary Disease in Hispanics
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Genetic Epidemiology of COPD in Costa Rica
Status:
COMPLETED
Status Verified Date:
2012-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to examine genetic factors that influence the development of chronic obstructive pulmonary disease COPD in Hispanics a minority group at high risk for the disease
Detailed Description:
DESIGN NARRATIVE
This study will concentrate on a genetically isolated Hispanic population with a high prevalence of COPD living in the Central Valley of Costa Rica Nine hundred individuals from descendants of the Costa Rican Central Valley founder population will be enrolled To identify regions of the genome that are likely to contain genetic determinants of COPD-related phenotypes in this population the study will collect phenotypic and genotypic data on 30 large families with a history of moderate to severe COPD that have multiple individuals affected with smoking-related airflow obstruction A genome scan will be conducted on these individuals using short-tandem repeat STR markers Linkage analysis will be performed on 6 COPD-related phenotypes which will include the following 1 chronic bronchitis 2 airflow obstruction 3 forced expiratory volume in one second FEV1 4 FEV1FVCforced vital capacity5 bronchodilator responsiveness and 6 total serum immunoglobulin E Within genomic regions demonstrating linkage to COPD-related phenotypes in the genome scan narrowly spaced STR markers will be genotyped and tested for linkage between these markers and COPD-related phenotypes Within selected genomic regions the association will be tested between single nucleotide polymorphisms SNPs in candidate genes and COPD-related phenotypes By enrolling a large number of participants of a genetically isolated population and utilizing a family-based study design this study should be able to address an important yet unstudied issue the genetic influences on the expression of the COPD phenotype in Hispanics
This study will concentrate on a genetically isolated Hispanic population with a high prevalence of COPD living in the Central Valley of Costa Rica Nine hundred individuals from descendants of the Costa Rican Central Valley founder population will be enrolled To identify regions of the genome that are likely to contain genetic determinants of COPD-related phenotypes in this population the study will collect phenotypic and genotypic data on 30 large families with a history of moderate to severe COPD that have multiple individuals affected with smoking-related airflow obstruction A genome scan will be conducted on these individuals using short-tandem repeat STR markers Linkage analysis will be performed on 6 COPD-related phenotypes which will include the following 1 chronic bronchitis 2 airflow obstruction 3 forced expiratory volume in one second FEV1 4 FEV1FVCforced vital capacity5 bronchodilator responsiveness and 6 total serum immunoglobulin E Within genomic regions demonstrating linkage to COPD-related phenotypes in the genome scan narrowly spaced STR markers will be genotyped and tested for linkage between these markers and COPD-related phenotypes Within selected genomic regions the association will be tested between single nucleotide polymorphisms SNPs in candidate genes and COPD-related phenotypes By enrolling a large number of participants of a genetically isolated population and utilizing a family-based study design this study should be able to address an important yet unstudied issue the genetic influences on the expression of the COPD phenotype in Hispanics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL073373 | NIH | None | httpsreporternihgovquickSearchR01HL073373 |