Ignite Creation Date:
2024-05-05 @ 11:41 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00104637
Status:
COMPLETED
Last Update Posted:
2012-05-21
First Post:
2005-03-03
Brief Title:
Sildenafil for Chronic Obstructive Pulmonary Disease
Sponsor:
Kawut Steven MD
Organization:
Kawut Steven MD
Study Overview
Official Title:
A Double-blind Placebo-controlled Crossover Study of Sildenafil in Patients With Chronic Obstructive Pulmonary Disease
Status:
COMPLETED
Status Verified Date:
2012-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine if sildenafil improves the exercise capacity and lung function of patients with chronic obstructive pulmonary disease
Detailed Description:
Patients with chronic obstructive pulmonary disease COPD suffer from impaired exercise capacity and quality-of-life largely related to shortness of breath Many of the therapies currently available for COPD are aimed at improving these factors Exercise capacity is limited in part by high blood pressure in the blood vessels in the lungs Sildenafil also known as Viagra is an FDA-approved therapy for male erectile dysfunction One of its effects is to relax or open the lung vessels thereby lowering the blood pressure in the lungs We hypothesize that sildenafil will result in an improvement in exercise capacity quality-of-life and shortness of breath
Enrolled subjects will receive sildenafil or placebo for 4 weeks followed by exercise tests breathing tests and administration of quality-of-life questionnaires Subjects will then receive placebo or sildenafil whichever one they did not receive for the first 4 weeks for another 4 weeks followed by the same testing
Enrolled subjects will receive sildenafil or placebo for 4 weeks followed by exercise tests breathing tests and administration of quality-of-life questionnaires Subjects will then receive placebo or sildenafil whichever one they did not receive for the first 4 weeks for another 4 weeks followed by the same testing
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None