Ignite Creation Date:
2024-05-06 @ 12:31 AM
Last Modification Date:
2024-10-26 @ 10:51 AM
Study NCT ID:
NCT01599533
Status:
COMPLETED
Last Update Posted:
2019-12-02
First Post:
2012-04-10
Brief Title:
Screening for Thoracic Aortic Aneurysm Among a Cohort of Patients With a Degenerative Abdominal Aortic Aneurysm
Sponsor:
Assistance Publique Hopitaux De Marseille
Organization:
Assistance Publique Hopitaux De Marseille
Study Overview
Official Title:
Screening for Thoracic Aortic Aneurysm Among a Cohort of Patients With a Degenerative Abdominal Aortic Aneurysm Prevalence Description of the Different Thoracic Aortic Phenotypes by Aortic Volumetric Numerized Imaging and Their Relationship With Epidemiologic Clinical Biological and Genetic Factors
Status:
COMPLETED
Status Verified Date:
2019-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Many publications deal with the natural history of aortic aneurysms in literature Except for connective tissue disorders as Marfan or Loeys-Dietz syndrome aortic aneurysms are a complex multifactorial disease with genetic and environmental risk factors Susceptibility loci identified in thoracic aortic aneurysms TAA and abdominal aortic aneurysms AAA do not overlap suggesting that different genetic risk factors contribute to these two forms of aneuryms With a higher prevalence correlated to ageing 5 AAA is usually presented as the degenerative form of the disease However a recent epidemiologic study by Olsson et al has revealed an increasing incidence of thoracic aortic disease among older individuals 70-12 years with 60 of aneurysmal rupture or dissection at diagnosis and a 17 1 male-to-female ratio compared to 61 in AAA From this current knowledge arises the concept of diffuse or plurisegmental degenerative aneurysmal aortic disease poorly explored so far As regards to the prevention policy there is a consensus statement in which ultrasonography screening for AAA is recommended for all individuals aged 60 years particularly in men who have ever smoked and for those aged 50 years with family history of AAA Nevertheless screening for a concomittant thoracic location of the disease except thoracoabdominal aneurysm is not yet required whereas it could change the prognosis of the patients and influence their management
Detailed Description:
Through the constitution of a multicentric prospective cohort of patients with infra-renal AAA n450 the investigators aimed to determine the prevalence of a concomitant TAA and the epidemiologic clinical biological and genetic factors related to this aortic phenotype Therefore the investigators postulate for a prevalence of the AAA-TAA association inferior or equal to 15 By the use of an innovating software AMIRA to analyse scans the investigators will perform reproductive measurements of segmental diameters from a segmental aortic volumetric numerized imaging and describe the different thoracic aortic phenotypes associated with AAA including the form TAA penetrating ulcer dolichoaorta and the location of the disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2012-01 | OTHER | AP HM | None |