Ignite Creation Date:
2025-12-25 @ 3:13 AM
Ignite Modification Date:
2025-12-26 @ 1:52 AM
Study NCT ID:
NCT05905705
Status:
RECRUITING
Last Update Posted:
2025-01-28
First Post:
2023-06-06
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Sponsor:
Washington University School of Medicine
Organization:
Study Overview
Official Title:
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy
Status:
RECRUITING
Status Verified Date:
2025-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DNS-ECT
Brief Summary:
Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.
Detailed Description:
Graph-based network analyses of electroencephalographic (EEG) signals allow characterization of functional networks. The robustness of local networks to disruption is quantified as local efficiency (Elocal), while network integration is quantified as global information transfer (Eglobal).
Aim 1: Assess relationships between sleep slow-wave activity (SWA) and awake Elocal over the course of ECT.
Aim 2: Quantify relationships between depression severity and awake Elocal over the course of ECT.
Aim 1: Assess relationships between sleep slow-wave activity (SWA) and awake Elocal over the course of ECT.
Aim 2: Quantify relationships between depression severity and awake Elocal over the course of ECT.
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
Secondary ID Infos
| Secondary ID | Type | Domain | Link | View |
|---|---|---|---|---|
| K01MH128663 | NIH | None | https://reporter.nih.gov/quic… | View |