Ignite Creation Date:
2024-05-06 @ 12:29 AM
Last Modification Date:
2024-10-26 @ 10:50 AM
Study NCT ID:
NCT01582165
Status:
COMPLETED
Last Update Posted:
2016-09-27
First Post:
2012-04-16
Brief Title:
Women With Chest Pain and no Significant Coronary Artery Stenosis A Study on Microvascular Resistance
Sponsor:
Oslo University Hospital
Organization:
Oslo University Hospital
Study Overview
Official Title:
Microvascular Resistance in Women With Chest Pain and no or Minimal Coronary Artery Disease
Status:
COMPLETED
Status Verified Date:
2016-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Female patients presenting with persistent chest pain despite no obstructive coronary artery disease have impaired prognosis Stress tests are often positive or inconclusive As much as 20 of women with chest pain and minimal angiographic CAD have evidence of myocardial ischemia suggesting impaired coronary microcirculation The index of microvascular resistance IMR is a method for indirectly investigating microvascular function in the cardiac catheterization laboratory
66 female patients age 30-70 years with chest pain and normal or near normal coronary angiograms will be included After coronary physiologic evaluation patients will be randomized in a double blind study to rosuvastatin 20 mgday or matching placebo tablets for altogether 6 months
The investigators hypothesize that
1 A substantial number of women with chest pain and normal or minimal pathology on angiograms have microvascular dysfunction defined by a raised IMR
2 Statins based on its pleiotropic action will improve endothelial function and thereby IMR
66 female patients age 30-70 years with chest pain and normal or near normal coronary angiograms will be included After coronary physiologic evaluation patients will be randomized in a double blind study to rosuvastatin 20 mgday or matching placebo tablets for altogether 6 months
The investigators hypothesize that
1 A substantial number of women with chest pain and normal or minimal pathology on angiograms have microvascular dysfunction defined by a raised IMR
2 Statins based on its pleiotropic action will improve endothelial function and thereby IMR
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2011-002630-39 | EUDRACT_NUMBER | None | None |