Ignite Creation Date:
2024-05-06 @ 12:27 AM
Last Modification Date:
2024-10-26 @ 10:50 AM
Study NCT ID:
NCT01578018
Status:
COMPLETED
Last Update Posted:
2012-08-10
First Post:
2012-04-11
Brief Title:
Tumor Markers in Lung Cancer DCAMLK-1LK-1
Sponsor:
University of Oklahoma
Organization:
University of Oklahoma
Study Overview
Official Title:
Tumor Markers in Lung Cancer DCAMLK-1LK-1 A Pilot Study
Status:
COMPLETED
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
DCAMLK1 is a Ca2 - camodulin CaM - dependent protein kinase that is a marker of stem cells in colonic crypts Mutations within the stem cell population are thought to be responsible for the development of most colorectal carcinomas and studies have shown that DCAMLK1 is highly expressed in these tumors Since the lung is an embryological development of the foregut the investigators speculate that DCAMLK1 will also be upregulated in lung cancers
The aim of this pilot study is to measure DCAMLK1 levels in the blood of patients with suspected malignant and benign lung diseases and to correlate DCAMKL1 levels with smoking status
The aim of this pilot study is to measure DCAMLK1 levels in the blood of patients with suspected malignant and benign lung diseases and to correlate DCAMKL1 levels with smoking status
Detailed Description:
In the investigators preliminary study DCAMKL1 antigen was detected not only in malignant tissue but also in BAL fluid from patients with benign lung disease This suggests that DCAMKL1 expression might be induced by smoking or benign lung diseases To examine this hypothesis the investigators will compare DCAMLK1 expression in blood from patients with lung cancer to controls who are current or former smokers with benign lung disease
Previous work has showed that DCAMLK1 is not detectable in the blood of healthy non smoking individuals To determine whether smoking and or pulmonary inflammation induce DCAMLK1 expression the investigators will obtain serum samples from 20 control patients with lung disease who are seen in the Chest Clinic at the Oklahoma City VAMC Smoking histories will be obtained for all participants and DCAMLK1 levels will be correlated with smoking status
Previous work has showed that DCAMLK1 is not detectable in the blood of healthy non smoking individuals To determine whether smoking and or pulmonary inflammation induce DCAMLK1 expression the investigators will obtain serum samples from 20 control patients with lung disease who are seen in the Chest Clinic at the Oklahoma City VAMC Smoking histories will be obtained for all participants and DCAMLK1 levels will be correlated with smoking status
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None