Ignite Creation Date:
2024-05-06 @ 12:27 AM
Last Modification Date:
2024-10-26 @ 10:49 AM
Study NCT ID:
NCT01570556
Status:
UNKNOWN
Last Update Posted:
2012-04-04
First Post:
2012-03-15
Brief Title:
Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients
Sponsor:
Assaf-Harofeh Medical Center
Organization:
Assaf-Harofeh Medical Center
Study Overview
Official Title:
Clinical Impact of Bacteriuria on Chronic Inflammation in Asymptomatic Hemodialysis Patients
Status:
UNKNOWN
Status Verified Date:
2012-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
When considering occult infections during the diagnostic workup of inflammation in Hemodialysis HD patients the urine-deprived bladder is frequently dismissed as potential site of infection The urinary tract even in end stage renal disease ESRD patients on hemodialysis may represent a significant reservoir for infection Delayed diagnosis is a relevant issue because the urinary tract is often overlooked as a source of infection in dialysis patients especially because of absence of urinary tract infection UTI symptoms in HD patients Contributing factors to asymptomatic UTI in HD patients include the presence of low urine volume bladder stasis and the fact that UTI symptoms are mostly related to voiding which is reduced or absent in these patients Persistence of asymptomatic bacteriuria and UTI may be related to higher levels of inflammatory markers in HD population In view of the association between cardiovascular disease and cardio-vascular and all-cause mortality with inflammation as expressed by elevated CRP andor IL-6 levels in HD patients the investigators questioned whether presence of asymptomatic UTI could contribute to elevated levels of inflammatory markers in patients with ESRD on maintenance HD therapy Such a finding would provide a potential link between a treatable infection and a potential cardiovascular risk factor in this population
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None