Ignite Creation Date:
2024-05-06 @ 12:27 AM
Last Modification Date:
2024-10-26 @ 10:49 AM
Study NCT ID:
NCT01570075
Status:
UNKNOWN
Last Update Posted:
2012-04-04
First Post:
2012-03-28
Brief Title:
Radiofrequency Ablation Versus Liver Resection for Elderly Patients With Hepatocellular Carcinoma HCC Within the Milan Criteria
Sponsor:
Sun Yat-sen University
Organization:
Sun Yat-sen University
Study Overview
Official Title:
Radiofrequency Ablation Versus Liver Resection for Elderly Patients With Hepatocellular Carcinoma HCC Within the Milan Criteria
Status:
UNKNOWN
Status Verified Date:
2012-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Hepatocellular carcinoma HCC is a common cancer and it is the third commonest global cause of cancer-related death With an increase in life-expectancy of the general population the number of elderly with HCC is expected to increase Current curative treatment options for HCC include liver transplantation liver resection LR and local ablation therapy Liver transplantation is a good treatment for HCC within the Milan criteria single HCC 5 cm or up to 3 nodules each 3 cm As a consequence of the lack of liver donors one relative contraindication for liver transplantation is age over 65 years or the protocol requires elderly patients to have very good general health before they can be put on a transplant list Transcatheter arterial chemoembolization TACE is used more commonly for the treatment of intermediate and advanced-staged HCC while liver resection and local ablation therapy are used for early-staged HCC Amongst the local ablative therapies radiofrequency ablation RFA is most widely used It has the advantage of minimally invasiveness making it the first-line treatment for small HCC in patients with compromised liver function or associated severe medical conditions
Elderly patients are more likely to have poor general conditions and associated medical diseases RFA has the advantage of being less invasive and it causes less pain less blood loss and earlier recovery than LR On the other hand incomplete ablation of HCC and tumor track seeding may happen Several studies have demonstrated the safety of LR for elderly patients There is no good evidence in the medical literature to support whether RFA or LR is a better treatment for elderly patients with HCC
Elderly patients are more likely to have poor general conditions and associated medical diseases RFA has the advantage of being less invasive and it causes less pain less blood loss and earlier recovery than LR On the other hand incomplete ablation of HCC and tumor track seeding may happen Several studies have demonstrated the safety of LR for elderly patients There is no good evidence in the medical literature to support whether RFA or LR is a better treatment for elderly patients with HCC
Detailed Description:
Hepatocellular carcinoma HCC is a common cancer and it is the third commonest global cause of cancer-related death With an increase in life-expectancy of the general population the number of elderly with HCC is expected to increase Current curative treatment options for HCC include liver transplantation liver resection LR and local ablation therapy Liver transplantation is a good treatment for HCC within the Milan criteria single HCC 5 cm or up to 3 nodules each 3 cm As a consequence of the lack of liver donors one relative contraindication for liver transplantation is age over 65 years or the protocol requires elderly patients to have very good general health before they can be put on a transplant list Transcatheter arterial chemoembolization TACE is used more commonly for the treatment of intermediate and advanced-staged HCC while liver resection and local ablation therapy are used for early-staged HCC Amongst the local ablative therapies radiofrequency ablation RFA is most widely used It has the advantage of minimally invasiveness making it the first-line treatment for small HCC in patients with compromised liver function or associated severe medical conditions
Elderly patients are more likely to have poor general conditions and associated medical diseases RFA has the advantage of being less invasive and it causes less pain less blood loss and earlier recovery than LR On the other hand incomplete ablation of HCC and tumor track seeding may happen Several studies have demonstrated the safety of LR for elderly patients There is no good evidence in the medical literature to support whether RFA or LR is a better treatment for elderly patients with HCC
Elderly patients are more likely to have poor general conditions and associated medical diseases RFA has the advantage of being less invasive and it causes less pain less blood loss and earlier recovery than LR On the other hand incomplete ablation of HCC and tumor track seeding may happen Several studies have demonstrated the safety of LR for elderly patients There is no good evidence in the medical literature to support whether RFA or LR is a better treatment for elderly patients with HCC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None