Ignite Creation Date:
2024-05-06 @ 12:26 AM
Last Modification Date:
2024-10-26 @ 10:49 AM
Study NCT ID:
NCT01572077
Status:
COMPLETED
Last Update Posted:
2018-04-13
First Post:
2012-03-29
Brief Title:
Rt Ventricular Substrate Metabolism as a Predictor of Rt Heart Failure in Patients With Pulmonary Arterial Hypertension
Sponsor:
Ottawa Heart Institute Research Corporation
Organization:
Ottawa Heart Institute Research Corporation
Study Overview
Official Title:
Rt Ventricular Substrate Metabolism as a Predictor of Rt Heart Failure in Patients With Pulmonary Arterial Hypertension
Status:
COMPLETED
Status Verified Date:
2018-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RVMET
Brief Summary:
The purpose of this study is to evaluate patterns of metabolic activity in the heart of patients with pulmonary arterial hypertensionPAH Patients with PAH are at risk of developing weakness or failure of the right side of the heartIt is possible that there is a relationship between the development of heart failure and the way the heart uses energy sources such as sugar This study is designed to evaluate the way the heart uses sugar uptake in patients with PAH using positron emission tomographyPET imaging
Detailed Description:
PAH results in premature death as a result of right ventricular dysfunction However there are substantial differences among patients in their tendency to develop right heart failure This study proposes to determine if right ventricular RV changes can predict the development of right heart failure in patients with PAH
In addition the study aims to evaluate the relationship of right ventricular metabolism to other physiologic responses in PAHincludingpulmonary vascular resistance serum BNP and changes in cardiac hypertrophy and function In conjunction with hemodynamic measurements biomarkers and cardiac magnetic resonance imaging MRI RV metabolism will be evaluated with 18F FTHA and 18FFDG cardiac PET imaging
A cohort of 20 age sex matched individuals will serve as normal controls These subjects will have no known cardiac or pulmonary disease with normal ventricular function and estimates pulmonary pressures on echocardiogram
In addition the study aims to evaluate the relationship of right ventricular metabolism to other physiologic responses in PAHincludingpulmonary vascular resistance serum BNP and changes in cardiac hypertrophy and function In conjunction with hemodynamic measurements biomarkers and cardiac magnetic resonance imaging MRI RV metabolism will be evaluated with 18F FTHA and 18FFDG cardiac PET imaging
A cohort of 20 age sex matched individuals will serve as normal controls These subjects will have no known cardiac or pulmonary disease with normal ventricular function and estimates pulmonary pressures on echocardiogram
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None