Ignite Creation Date:
2024-05-06 @ 12:26 AM
Last Modification Date:
2024-10-26 @ 10:50 AM
Study NCT ID:
NCT01578616
Status:
COMPLETED
Last Update Posted:
2015-08-07
First Post:
2012-04-11
Brief Title:
Endothelial Dysfunction and Plaque Vulnerability
Sponsor:
Yokohama City University Medical Center
Organization:
Yokohama City University Medical Center
Study Overview
Official Title:
Association of Endothelial Function With Plaque Vulnerability Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome
Status:
COMPLETED
Status Verified Date:
2015-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Thinning of fibrous cap in atherosclerotic plaques is associated with plaque vulnerability The high resolution of optical coherence tomography OCT provides an accurate measurement of fibrous cap thickness Endothelial dysfunction is a key component of vulnerable plaque and digital reactive hyperemia-peripheral arterial tonometry RH-PAT is a non-invasive automatic and quantitative method to evaluate endothelial function The investigators will investigate the association between endothelial function assessed by RH-PAT and plaque vulnerability determined by OCT-derived thin-cap fibroatheroma TCFA
Detailed Description:
Consecutive patients with acute coronary syndrome ACS who undergo both OCT examination and RH-PAT examination are enrolled OCT examination is performed to observe the culprit lesion before percutaneous coronary intervention and endothelial function is evaluated using RH-PAT before discharge
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None