Ignite Creation Date:
2024-05-06 @ 12:25 AM
Last Modification Date:
2024-10-26 @ 10:49 AM
Study NCT ID:
NCT01574209
Status:
COMPLETED
Last Update Posted:
2012-11-09
First Post:
2012-03-28
Brief Title:
Gut Peptides and Intestinal Permeability in Celiac Disease and Irritable Bowel Syndrome
Sponsor:
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Organization:
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Study Overview
Official Title:
Gut Peptides and Intestinal Permeability in Celiac Patients Healthy Subjects and IBS Patients a Comparative Study
Status:
COMPLETED
Status Verified Date:
2012-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PPCD
Brief Summary:
It is well known that the intestinal barrier is altered in celiac disease CD an autoimmune disease that develops in genetically predisposed subjects exposed to ingestion of wheat gliadin and of related prolamines of barley and rye More recently defective epithelial barrier has been implicated in the pathogenesis of other conditions such as irritable bowel syndrome IBS At present IBS is still considered a functional condition although low-grade inflammation has been associated with its manifestation particularly that following infection Different substances have been implicated in the disregulation of intestinal barrier among them zonulin seems to play a key role Other gastrointestinal peptides are GPL-2 Ghrelin and Epidermal growth factor EGF In order to shed light on the hormonal regulation of intestinal barrier function in celiac patients before undergoing a gluten free diet and possible differences with those of IBS patients in the present study the investigators will apply the non-invasive lactulosemannitol permeability test toward the evaluation of intestinal damage The pattern of intestinal permeability and the GI peptides concentration will be compared in celiac patients IBS patients and healthy controls
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None