Ignite Creation Date:
2024-05-06 @ 12:24 AM
Last Modification Date:
2024-10-26 @ 10:49 AM
Study NCT ID:
NCT01566539
Status:
COMPLETED
Last Update Posted:
2017-09-25
First Post:
2012-03-26
Brief Title:
Biological Basis of Individual Variation in Social Cooperation
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
The Biological Basis of Individual Variation in Social Cooperation
Status:
COMPLETED
Status Verified Date:
2017-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The project has three overall objectives The first is to determine whether and how administration of intranasal oxytocin OT and intranasal vasopressin AVP influence cooperative decision-making and neural responses to cooperative and un-cooperative social interactions The second is to determine whether and how intranasal vasopressin influences subjective evaluations of and neural responses to same and opposite-sex face stimuli and to determine if any of these effects persist beyond the period of AVP exposure The third objective is to determine if intranasal OT influences empathy-related behavior and associated brain activity
Detailed Description:
There are several objective to the study
Objective 1 In this double-blind placebo-controlled pharmaco- fMRI study men and women will be randomized to treatment with either 24 IU intranasal OT 20 IU intranasal AVP or placebo PL Approximately 40 minutes later brain function will be imaged with fMRI as participants play an iterated Prisoners Dilemma game with same-sex partners The resulting data will be analyzed to investigate OT and AVP effects on cooperative behavior and the neural response to cooperative social interactions
In addition to this cross-sectional design a subset of participants will return on a second day for a within-subject study
Objective 2 Men and healthy women will be randomized to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 minutes before their brain function is measured with fMRI as they view same and other-sex faces All subjects will be scanned a second time several days later with no treatment to evaluate the persistence of AVP effects over time The resulting data will be analyzed to investigate AVP effects on subjective evaluations and neural responses to viewing same and opposite sex faces
Objective 3 Healthy men and healthy women will receive either 24IU intranasal OT or PL approximately 40 minutes before their brain function is measured with fMRI as they view animations of geometric shapes depicting either random movement or social interactions such as playing chasing fighting All participants will receive PL on scan 1 and will be randomized to either 24IU intranasal OT or PL on scan 2 The resulting data will be analyzed to investigate OT effects on subjective evaluations and neural responses to the animations
Objective 1 In this double-blind placebo-controlled pharmaco- fMRI study men and women will be randomized to treatment with either 24 IU intranasal OT 20 IU intranasal AVP or placebo PL Approximately 40 minutes later brain function will be imaged with fMRI as participants play an iterated Prisoners Dilemma game with same-sex partners The resulting data will be analyzed to investigate OT and AVP effects on cooperative behavior and the neural response to cooperative social interactions
In addition to this cross-sectional design a subset of participants will return on a second day for a within-subject study
Objective 2 Men and healthy women will be randomized to treatment with either 40 IU intranasal AVP or a saline placebo approximately 30 minutes before their brain function is measured with fMRI as they view same and other-sex faces All subjects will be scanned a second time several days later with no treatment to evaluate the persistence of AVP effects over time The resulting data will be analyzed to investigate AVP effects on subjective evaluations and neural responses to viewing same and opposite sex faces
Objective 3 Healthy men and healthy women will receive either 24IU intranasal OT or PL approximately 40 minutes before their brain function is measured with fMRI as they view animations of geometric shapes depicting either random movement or social interactions such as playing chasing fighting All participants will receive PL on scan 1 and will be randomized to either 24IU intranasal OT or PL on scan 2 The resulting data will be analyzed to investigate OT effects on subjective evaluations and neural responses to the animations
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01MH084068-01A1 | NIH | None | None |
| MH087721-01A1 | OTHER | NIMH | httpsreporternihgovquickSearch1R01MH084068-01A1 |