Ignite Creation Date:
2024-05-05 @ 11:40 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00106652
Status:
COMPLETED
Last Update Posted:
2017-09-25
First Post:
2005-03-28
Brief Title:
Childhood Autism Risks From Genetics and the Environment The CHARGE Study
Sponsor:
National Institute of Environmental Health Sciences NIEHS
Organization:
National Institute of Environmental Health Sciences NIEHS
Study Overview
Official Title:
Environmental Factors in the Etiology of Autism
Status:
COMPLETED
Status Verified Date:
2017-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to understand how genes environment and the interplay between the two influences the development of autism and other neurodevelopmental disorders
Detailed Description:
The causes and contributing factors for autism are poorly understood Evidence suggests that incidence is increasing but diagnostic changes and improvements may be playing a role Both genetic and environmental factors appear to play a role Autopsy studies demonstrate structural changes in the brain and clinical investigations reveal neurophysiologic differences in information processing in autistic versus normal children Members of our team recently demonstrated altered levels of certain neuropeptides at birth in children who later developed autism
This case-control study is the first large-scale epidemiologic investigation of underlying causes for autism and triggers of regression This study capitalizes on the strengths of the case-control design which is well suited to examine a broad array of factors for rare conditions that are thought to be multifactorial Comparisons will be made with both general population controls and mentally retarded children
The aims are to assess the influence of exogenous exposures the role of susceptibility factors and the interplay between these two in the etiology of autism and its phenotypic variation Chemicals with known or suspected neurodevelopmental toxicity such as PCBs certain pesticides and metals are being investigated This study pursues several hypotheses that have recently gained attention including the combined measles mumps rubella vaccine and mercury present in vaccines given during infancy and early childhood Additionally biochemical susceptibility is examined through characterization of metabolic immunologic and neuronal gene expression profiles and genetic polymorphisms
This case-control study is the first large-scale epidemiologic investigation of underlying causes for autism and triggers of regression This study capitalizes on the strengths of the case-control design which is well suited to examine a broad array of factors for rare conditions that are thought to be multifactorial Comparisons will be made with both general population controls and mentally retarded children
The aims are to assess the influence of exogenous exposures the role of susceptibility factors and the interplay between these two in the etiology of autism and its phenotypic variation Chemicals with known or suspected neurodevelopmental toxicity such as PCBs certain pesticides and metals are being investigated This study pursues several hypotheses that have recently gained attention including the combined measles mumps rubella vaccine and mercury present in vaccines given during infancy and early childhood Additionally biochemical susceptibility is examined through characterization of metabolic immunologic and neuronal gene expression profiles and genetic polymorphisms
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 200210574-4 | None | None | None |