Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005107
Status:
UNKNOWN
Last Update Posted:
2005-06-24
First Post:
2000-04-11
Brief Title:
Role of Nitric Oxide in Cirrhosis Relationship With Systemic Hemodynamics Renal Function Vasoactive Systems and Endotoxemia
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2003-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is to determine whether a compound nitric oxide made within the body is the factor responsible for the changes in blood pressure and renal kidney functions that may occur during the course of cirrhosis Patients with cirrhosis liver scarring which causes poor liver function will be eligible to participate A group of healthy subjects will also be studied to compare the effects of the treatment to patients with cirrhosis and to confirm safety A total number of 30 patients with cirrhosis and 10 healthy subjects will be enrolled in the study
Detailed Description:
Upon admission the patients will be physically examined and started on a special diet that will continue throughout the study During the first four days of the study the weight heart rate and blood pressure of the patients will be measured every morning and 24-hour urine will be collected On day 5 intravenous lines will be inserted in the patients arms One line will be used to draw blood samples and the other line will be used to infuse medications Blood samples will be taken to measure liver and kidney function nitric oxide and other hormones that participate in the regulation of body fluids and blood pressure Inulin and paraaminohippurate infusions substances used routinely in the study of kidney function will be started and blood and urine samples will then be taken at periodic intervals Ninety minutes after the initiation of inulin and PAH infusions L-NMMA an investigational drug expected to increase the blood pressure and improve the kidney functions will be infused Blood and urine samples will be collected every 30 minutes These procedures will take 4 hours A total amount of about 10 tablespoons of blood will be drawn during the study The patients will be discharged from the GCRC the next morning and restarted on their regular medications
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| M01RR000051 | NIH | None | httpsreporternihgovquickSearchM01RR000051 |