Ignite Creation Date:
2024-05-06 @ 12:19 AM
Last Modification Date:
2024-10-26 @ 10:48 AM
Study NCT ID:
NCT01548625
Status:
COMPLETED
Last Update Posted:
2012-03-08
First Post:
2012-03-05
Brief Title:
Cardiovascular Effects of Incremental Diesel Exhaust Inhalation in Middle-Aged Healthy GSTM1 Null Human Volunteers
Sponsor:
Environmental Protection Agency EPA
Organization:
Environmental Protection Agency EPA
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2012-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Purpose A growing body of epidemiological data suggests an increased risk of cardiovascular events associated with air pollutants Reactive oxygen species ROS have been implicated as a potential mechanism for the adverse effects of air pollutants and genetic polymorphisms of the glutathione-s-transferases GSTs have been shown to participate in the antioxidant defenses to air pollutants This study examined the dose effects of diesel exhaust exposure on the cardiovascular system in healthy middle-aged subjects
Participants Six healthy 50-75 year-old male and female subjects with GSTM1 null genotype had 3 sequential exposures to the diesel exhausts at concentrations approximately 100 µgm3 200 µgm3 and 300 µgm3 for 2 hours with a about 2 weeks of interval between exposures
Participants Six healthy 50-75 year-old male and female subjects with GSTM1 null genotype had 3 sequential exposures to the diesel exhausts at concentrations approximately 100 µgm3 200 µgm3 and 300 µgm3 for 2 hours with a about 2 weeks of interval between exposures
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None