Ignite Creation Date:
2024-05-06 @ 12:18 AM
Last Modification Date:
2024-10-26 @ 10:48 AM
Study NCT ID:
NCT01548521
Status:
COMPLETED
Last Update Posted:
2017-02-23
First Post:
2011-12-30
Brief Title:
Tolerance of Intranasal Administration of OT in Prader-Willi Newborn Babies
Sponsor:
University Hospital Toulouse
Organization:
University Hospital Toulouse
Study Overview
Official Title:
Tolerance of Intranasal Administration of OT in Prader-Willi Newborn Babies and Effect on Suck and Food Intake
Status:
COMPLETED
Status Verified Date:
2017-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
OTBB
Brief Summary:
Background Prader-Willi syndrome PWS is a rare complex multisystem genetic disorder arising from the lack of expression of paternally inherited imprinted genes on chromosome 15q11-q13 The syndrome includes severe neonatal hypotonia with impaired suckling leading to failure to thrive in the most severe cases subsequently followed by an early onset of morbid obesity with insatiable hunger combined with other endocrine dysfunction probably due to hypothalamic dysfunction The pathophysiological mechanism of the occurrence of the 2 main nutritional phases of PWS is unknown A deficit in the oxytocin OT-producing neurons of the paraventricular nucleus in the brain of these patients has been reported In addition of its well-known anorexigenic effect OT is involved in establishing and maintaining social codes Indeed we have recently shown in a double blind placebo study that OT administration to adult patients with PWS significantly decreased depressive mood tendencies and tantrums while increasing trust in others with some data on a trend to decrease appetite with higher satiety Moreover in a PWS mouse model generated from a MAGEL2 KO gene a single OT injection at 5 hr of life prevent the early death observed in 50 of the new born mice by recovering normal suckling Interestingly this effect is no longer observed if OT injection takes place later These data OT deficit in PWS good tolerance of OT and its effect after intranasal administration in adult patients with PWS and the recent striking data obtained in the MAGEL2 mouse model prompted us to evaluate the tolerance of a single administration of intranasal OT in PWS newborns and its possible effect on suckling and food intake Nowadays the diagnosis of PWS is done during the first months of life in our country At this age children still present with poor suckling suggesting that OT may be still efficient Moreover in adult patients with PWS we have shown that OT improves some typical behavioral troubles Therefore we first want to evaluate the tolerance of the intranasal administration of OT in 6 infants with PWS genetically confirmed and its effect on suckling milk intake and weight gain
Detailed Description:
We want to evaluate the tolerance of the intranasal administration of OT in 6 infants with PWS genetically confirmed and its effect on suckling milk intake and weight gain The three first patients will have single nasal administration of 2 IU of Oxytocin and if no adverse event has been observed the 3 following patients will have single nasal administration of 4 IU of Oxytocin We will monitor cardiac pulse blood pressure urine emission and measure biological safety parameters glycemia natremia and kaliemia Video will be performed during 1 day before the drug administration and the 3 days after in order to qualify the suckling Quantitative evaluation of the milk intake during each feeding and per day will be also evaluated Biological parameters will be measured OT ghrelin others neuroendocrine hormones involved in appetite regulation leptin cortisol insulin GLP-1 PYY pancreatic polypeptide orexin A aMSH taking advantage of blood samples for safety biological measurements These infants will stay 8 days which is less than the mean duration of hospitalization of these infants with data records by phone at 1 month and then have a final visit after 3 months
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None