Ignite Creation Date:
2024-05-06 @ 12:18 AM
Last Modification Date:
2024-10-26 @ 10:48 AM
Study NCT ID:
NCT01548300
Status:
COMPLETED
Last Update Posted:
2018-02-08
First Post:
2012-03-05
Brief Title:
Environmental Triggers Of Cardiometabolic Disease
Sponsor:
Sanjay Rajagopalan
Organization:
University of Maryland Baltimore
Study Overview
Official Title:
Environmental Triggers Of Cardiometabolic Disease
Status:
COMPLETED
Status Verified Date:
2018-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
AIRCMD
Brief Summary:
The investigators posit that a multi-national collaborative effort with focused investigations in environments with the highest levels of exposure developing countries such as China and India are likely to provide new and much needed data on the risk posed by these variables on an individuals life-time risk for type 2 diabetes and cardiovascular complications The investigators will test this hypothesis through the establishment of a network that would lead studies on the links between exposure and adverse Chronic cardiometabolic effects and propose doing this in this as part of 3 specific aims
Detailed Description:
In aim 1 the investigators propose to establish feasibility of such an effort in Beijing China an effort that will involve implementation of novel exposure assessment methodologies simultaneously with the ability to execute key surrogate outcome measures of importance in cardiovascular risk with CM diseases In Aim 2 the association between functional cardiovascular risk variables insulin sensitivity Blood Pressure endothelial function and acute and sub-acute variations in personal black carbon and ambient particulate matter 25 levels among 50 individuals with the chronic cardiometabolic syndrome will be investigated In Aim 3 the investigators will examine potential biologic pathways of importance in the proposed functional outcomes Specifically the investigators will determine the association between ambient particulate matter 25 levels and alterations in adipocytokinesinflammatory variables and autonomic nervous system balance
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01ES019616 | NIH | None | httpsreporternihgovquickSearchR01ES019616 |