Ignite Creation Date:
2024-05-06 @ 12:15 AM
Last Modification Date:
2024-10-26 @ 10:47 AM
Study NCT ID:
NCT01529489
Status:
COMPLETED
Last Update Posted:
2012-02-08
First Post:
2012-02-02
Brief Title:
Effect of Two Physical Training Programs on Oxygen Uptake and Heart Rate On-kinetics in Patients COPD
Sponsor:
Universidade Federal de Sao Carlos
Organization:
Universidade Federal de Sao Carlos
Study Overview
Official Title:
Effect of the Combined AerobicResisted and Interval Physical Training on Oxygen Uptake and Heart Rate On-kinetics Responses in Patients With Moderate to Very Severe COPD Double-blind Randomized Controlled Trial
Status:
COMPLETED
Status Verified Date:
2012-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
BVPS-123
Brief Summary:
Patients with chronic obstructive pulmonary disease COPD present slowed pulmonary oxygen uptake VO2 and heart rate HR kinetics compared with age-matched controls Patients with COPD present significant loss of body mass decreased strength and endurance of respiratory muscles and lower limbs leading reduced exercise capacity This reduced exercise capacity can be marked by slowed kinetics of VO2 and HR at the onset of heavy-intensity exercise Additionally derangements in the diffusive and convective transport of oxygen to skeletal muscle mitocondria and intramyocyte metabolic machinery higher ventilation and disturbances in mechanics of breathing hypoxemia pulmonary hemodynamics autonomic balance and peripheral vasodilation and accumulation of by-products that might be related to increased muscle fatigability could slow the response of systemic central and peripheral microvascular oxygen delivery to a point where the kinetics of VO2 might become limited by O2 availability and HR Thus the physical training programs of the lower limbs in addition to presenting scientific evidence A are important components resulting in the reversal of the manifestations of COPD resulting in improvement in exercise capacity well significantly speeded VO2 and HR kinetics in patients with COPD However it should be taken into account the choice of an appropriate program limitations and severity of disease Assuming that COPD patients present slower VO2 and HR kinetics the investigators hypothesized that the heavy-intense interval physical training in equipament elliptical would promote a greater increase in the functionality functional performance and speeded kinetics in the cycle ergometer and elliptical equipment constant-load intense exercises tests of COPD patients In this context the present study intends to evaluate and compare the effects of resistive plus aerobic physical training and interval physical training on oxygen consumption VO2 and heart rate HR kinetics responses at the onset in cycle ergometer and elliptical equipment constant-load intense exercises tests in patients with COPD
Detailed Description:
Subjects performed after and before of two physical training program the following tests lung function testcardiopulmonary exercise testing CPT constant-load exercise test in cycle ergometer Constant-load exercise test in elliptical equipament one repetition maximum test1RM on alternate days
Lung function All patients underwent spirometry with the determination of FEV1 and FVC according to American Thoracic Society recommendations Spirometry was performed using a COSMED microQuark PC - based Spirometer Pavona di Albano - Roma Itália which was calibrated before each test
Cardiopulmonary Exercise Testing CPT Incremental symptom-limited exercise testing was performed on a cycle-ergometerErgo FIT model Ergo 167 Cycle Pirmasens Germany using a computer-based ventilatory expired gas analysis system VO2000 Medgraphics Corp St Paul MN All subjects underwent a CPT to determine the peak work rate and the peak oxygen uptake peak VO2 The subjects electrocardiographic recordings were monitored using a cardiac monitor SpO2 BP and sensation of dyspnea and fatigue using the BE-CR-10 A gas analyzer VO2000 Medgraphics St Paul MN USA was used to obtain the participants VO2 at each stage of the test The ergospirometric values were recorded by the mean value measured every three breaths using the Aerograph program The VO2 was determined choosing the higher and more coherent value in the final 30 seconds of each stage
Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical equipament The two exercise tests were performed at 70 of the previously determined work rate in CPT During the CSET VO2 was measured breath-by-breath and averaged every three respiration while SpO2 HR and the electrocardiogram were continuously monitored and calculated a on-Kinetics of VO2 and HR
Physical training program
The interval physical training on the elliptical trainer Kikos HM 6022 São Paulo SP Brazil totalized 18 sessions that the individuals of both groups had to attend at least twice a week Each session lasted not more than 60 minutes and they were all individual meetings The minimal work rate of the equipment was 40W and the lower increment work rate was 10W The elliptical trainer allowed combined exercise with the upper limb however in the present study the exercise was performed with the arms fixed and every participants HR was monitored using a pulse frequency meter Polar FS2cTM Kempele Finland the pulse oxygen saturation SpO2 using a pulse oximeter Nonin model 8500A Minneapolis Mn USA the blood pressure BP using a mercury sphygmomanometer Oxigel São Paulo SP Brazil and the sensation of dyspnea and lower limb fatigue using the Modified Borg CR-10 Scale BE-CR10 The elliptical exercise was an interval training and was based on studies that performed interval training exercise in cycle ergometer This was a 30-minute exercise with a rest interval established in one minute The exercises work rateworkload was the maximal achieved in the CPT and it was not modified until the sessions were finished The individuals who did not reach 40W in the CPT performed 30 seconds exercising periods at 40W with 1-minute resting interval The volunteers who achieved workload equal or higher 40W performed 1-minute exercising periods at the workload achieved in the CPT with 1-minute resting interval During the exercise on the equipment the individuals should keep the speed between 40 and 50 rpmVital signs HR BP SpO2 were recorded at the beginning and at the end of each session as well as monitored before during and after the elliptical exercise During the training the vital signs were recorded on the first 30 seconds of each resting interval
The aerobic associate resisted physical training consisted of thirty minutes oa aerobic training at 60-70 of work rate obtained in CPT and subsequently three sets of fifteen repetitions of resistance training in lower limbs on leg press with an intensity of 40-60 of one repetition maximum test
Lung function All patients underwent spirometry with the determination of FEV1 and FVC according to American Thoracic Society recommendations Spirometry was performed using a COSMED microQuark PC - based Spirometer Pavona di Albano - Roma Itália which was calibrated before each test
Cardiopulmonary Exercise Testing CPT Incremental symptom-limited exercise testing was performed on a cycle-ergometerErgo FIT model Ergo 167 Cycle Pirmasens Germany using a computer-based ventilatory expired gas analysis system VO2000 Medgraphics Corp St Paul MN All subjects underwent a CPT to determine the peak work rate and the peak oxygen uptake peak VO2 The subjects electrocardiographic recordings were monitored using a cardiac monitor SpO2 BP and sensation of dyspnea and fatigue using the BE-CR-10 A gas analyzer VO2000 Medgraphics St Paul MN USA was used to obtain the participants VO2 at each stage of the test The ergospirometric values were recorded by the mean value measured every three breaths using the Aerograph program The VO2 was determined choosing the higher and more coherent value in the final 30 seconds of each stage
Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical equipament The two exercise tests were performed at 70 of the previously determined work rate in CPT During the CSET VO2 was measured breath-by-breath and averaged every three respiration while SpO2 HR and the electrocardiogram were continuously monitored and calculated a on-Kinetics of VO2 and HR
Physical training program
The interval physical training on the elliptical trainer Kikos HM 6022 São Paulo SP Brazil totalized 18 sessions that the individuals of both groups had to attend at least twice a week Each session lasted not more than 60 minutes and they were all individual meetings The minimal work rate of the equipment was 40W and the lower increment work rate was 10W The elliptical trainer allowed combined exercise with the upper limb however in the present study the exercise was performed with the arms fixed and every participants HR was monitored using a pulse frequency meter Polar FS2cTM Kempele Finland the pulse oxygen saturation SpO2 using a pulse oximeter Nonin model 8500A Minneapolis Mn USA the blood pressure BP using a mercury sphygmomanometer Oxigel São Paulo SP Brazil and the sensation of dyspnea and lower limb fatigue using the Modified Borg CR-10 Scale BE-CR10 The elliptical exercise was an interval training and was based on studies that performed interval training exercise in cycle ergometer This was a 30-minute exercise with a rest interval established in one minute The exercises work rateworkload was the maximal achieved in the CPT and it was not modified until the sessions were finished The individuals who did not reach 40W in the CPT performed 30 seconds exercising periods at 40W with 1-minute resting interval The volunteers who achieved workload equal or higher 40W performed 1-minute exercising periods at the workload achieved in the CPT with 1-minute resting interval During the exercise on the equipment the individuals should keep the speed between 40 and 50 rpmVital signs HR BP SpO2 were recorded at the beginning and at the end of each session as well as monitored before during and after the elliptical exercise During the training the vital signs were recorded on the first 30 seconds of each resting interval
The aerobic associate resisted physical training consisted of thirty minutes oa aerobic training at 60-70 of work rate obtained in CPT and subsequently three sets of fifteen repetitions of resistance training in lower limbs on leg press with an intensity of 40-60 of one repetition maximum test
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None